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Summary RECEPTORS OF THE IMMUNE SYSTEM, PHAGOCYTIC CELLS, AND TOLERANCE
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RECEPTORS OF THE IMMUNE SYSTEM, PHAGOCYTIC CELLS, AND TOLERANCE  Receptors of the innate immune system mediate a number of different functions.  Many are phagocytic receptors that stimulate ingestion of the pathogens they recognize.  Some are chemotactic receptors, such as t...

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  • October 28, 2024
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RECEPTORS OF THE IMMUNE
SYSTEM,
PHAGOCYTIC CELLS, AND
TOLERANCE

, Receptors of the innate immune system mediate a number
different functions.
 Many are phagocytic receptors that stimulate ingestion of
pathogens they recognize.
 Some are chemotactic receptors, such as the f-Met-Leu-Ph
receptor, which binds the N-formylated peptides produced
bacteria, and guides neutrophils to sites of infection.
 A third function is to induce effector molecules, that contrib
the induced responses of innate immunity, and molecules t
influence the initiation and nature of subsequent adaptive
immune response.
 The surfaces of microorganisms typically bear repeating pa
of molecular structure.

, The innate immune system recognizes such pathogens by m
of receptors that bind features of these regular patterns; th
receptors are sometimes known as pattern-recognition
receptors/molecules (PRRs).
 The mannan-binding lectin (MBL) that initiates the MB-lectin
pathway of complement activation is an example of a PRR
 MBL is synthesized in the liver and released into circulation,
with a variety of other proteins from the collectin family (e.g
C1q).
 For this receptor, pathogen recognition and discrimination
self is due to recognition of a particular orientation and spa
of certain sugar residues, which is found only on pathogeni
microbes and not on host cells.

, Mannan-binding lectin (MBL
patterns of carbohydrate gro
correct spatial orientation.
MBL is a member of the colle
of proteins, composed of bet
to six clusters of carbohydra
lectin domains that interact
other via a collagen-like dom

Within each cluster are three
binding sites that have
orientation relative to each
three sites can therefore
when their ligands—mann
fucose residues in bacteria
polysaccharides—have
appropriate spacing.

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