PHARM II - EXAM 1 QUESTIONS AND ANSWERS
2024/2025 ALL ANSWERS CORRECT DETAILED
BEST GRADED A+ FOR SUCCESS
Gynecomastia; CYP DDI - CORRECT ANSWERS Cimetidine can cause ____ in men and is most
likely to have a ________
C. diff - CORRECT ANSWERS What risk do PPIs, PCABs, and H2RAs all have?
Constipation - CORRECT ANSWERS ADE of aluminum-containing antacids
Constipation - CORRECT ANSWERS ADE of calcium-containing antacids
Diarrhea - CORRECT ANSWERS ADE of magnesium-containing antacids
Hypernatremia - CORRECT ANSWERS ADE of sodium-containing antacids
Tetracyclines and FQs - CORRECT ANSWERS What meds can antacids decrease absorption
of?
Sucralfate - CORRECT ANSWERS Med that binds (+) charged proteins and create a past-like
barrier to treat GERD and peptic ulcers
Constipation - CORRECT ANSWERS ADE of sucralfate
PPIs - CORRECT ANSWERS Most effective med class for GERD
Studies were not definitive and do not establish cause/effect. Benefits far outweigh
theoretical risk - CORRECT ANSWERS You want to prescribe a Pt a PPI but they have
concerns that long-term use can cause pneumonia, stomach cancer, osteoporosis related
bone fractures, chronic kidney disease, deficiencies of certain vitamins and minerals, heart
attacks, strokes, dementia and/or early death. What should you explain to the Pt to put
them at ease?
,PHARM II - EXAM 1 QUESTIONS AND ANSWERS
2024/2025 ALL ANSWERS CORRECT DETAILED
BEST GRADED A+ FOR SUCCESS
>2 weeks - CORRECT ANSWERS Pt is taking OTC PPI treatment for GERD. After what length
of time should they see a provider if Sxs persist?
PPI QD x 4-8 weeks - CORRECT ANSWERS 1st line treatment for mod-severe, persistent
GERD
H2RA BID x 6-12 weeks - CORRECT ANSWERS 2nd line treatment for mod-severe, persistent
GERD
Dysphagia, Wt loss >10%, anemia, bleeding, vomitinh - CORRECT ANSWERS What are the
red flag Sxs to monitor when treating GERD?
Antacid or Sucralfate - CORRECT ANSWERS What should med should you try first for
pregnant women with GERD?
8-12 weeks - CORRECT ANSWERS If Pt is having extraesophageal Sxs, how long should they
stay on PPI to treat GERD?
Refractory GERD - CORRECT ANSWERS GERD not responding to optimal treatment after 8
weeks
Nocturnal Acid Breakthrough - CORRECT ANSWERS What is a sign that a Pt has refractory
GERD?
Relapse - CORRECT ANSWERS What can occur when stepping down in GERD treatment?
Duodenum - CORRECT ANSWERS Common location of H. pylori-caused ulcers
,PHARM II - EXAM 1 QUESTIONS AND ANSWERS
2024/2025 ALL ANSWERS CORRECT DETAILED
BEST GRADED A+ FOR SUCCESS
Erosion - CORRECT ANSWERS GI damage that is superficial and does not extend through
muscularis mucosa
Ulcer - CORRECT ANSWERS GI damage that extends through muscularis mucosa
Celebrex (COX-2 Selective) - CORRECT ANSWERS If Pt needs to take NSAID, which one would
reduce risk for ulcers?
MI, stroke, GI bleeding - CORRECT ANSWERS Black box warnings for NSAIDs
Potassium - CORRECT ANSWERS What ion is a proton pump exchanging in order to secrete
hydrogen ions into stomach lumen?
Does not require active acid secretion - CORRECT ANSWERS What makes a potassium-
competitive acid blocker (PCAB) different from a PPI?
Omeprazole - CORRECT ANSWERS PPI that is commonly prescribed
PRN - CORRECT ANSWERS PPI are slow acting and do not work for _____ use
Mg and B12 - CORRECT ANSWERS What vitamins/minerals could be become deficient while
taking a PPI?
Prodrug deactivation via CYP inhibition - CORRECT ANSWERS What DDI do PPIs have?
8 weeks - CORRECT ANSWERS PPIs have an 80% efficacy in improving Sx and mucosal
healing after ____ weeks
PCAB - CORRECT ANSWERS MOA of vonoprazan
, PHARM II - EXAM 1 QUESTIONS AND ANSWERS
2024/2025 ALL ANSWERS CORRECT DETAILED
BEST GRADED A+ FOR SUCCESS
2-3 hrs; 12-24 hrs - CORRECT ANSWERS How fast does vonoprazan start working? How long
does it last?
GERD and H. pylori - CORRECT ANSWERS What is the main use for vonoprazan?
H-2 Receptor Antagonist (H2RA) - CORRECT ANSWERS What med class is famotidine?
Decreases acid secretion - CORRECT ANSWERS What is the MOA of H2RAs?
30 mins; 4-10hrs - CORRECT ANSWERS How fast do H2RAs work? How long do they last?
Decrease by 50% - CORRECT ANSWERS Pt needs famotidine but has CrCl<50. What should
you do with the dosage?
Prostaglandins - CORRECT ANSWERS What do NSAIDs target to reduce inflammation but
inhibit its GI protective properties?
COX-1 - CORRECT ANSWERS What NSAID type affects GI lining?
PPI QD x 4 weeks + make NSAID changes - CORRECT ANSWERS Treatment for NSAID-induced
peptic ulcers
Misprostol - CORRECT ANSWERS NSAID-Induced Peptic ulcer med that acts as a
prostaglandin supplement
Explosive diarrhea - CORRECT ANSWERS Major ADE of misprostol
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