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2024 Update|NUR 641E final|COMPLETE FREQUENTLY MOST TESTED QUESTIONS WITH VERIFIED ANSWERS/ALREADY GREADED A+ |GET IT 100% ACCURATE!!$15.99
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, 10/30/24, 6:08 AM 2024 Update|NUR 641E final|COMPLETE FREQUENTLY MOST TESTED QUESTIONS WITH VERIFIED ANSWERS/ALRE…
how long it takes for half the drug to be excreted
from the body. Determines how frequently the drug
Half-life of a drug is must be administered. Predicts how long toxic
effects can last.is constant with first-order
pharmacokinetics of a drug.
Zero-order (nonlinear) means a drug is metabolized at a constant rate per
pharmacokinetics unit time.
may have enhanced activity if any CYP3A4 inducer
CYP3A4 substrate drugs
drugs are used along with it.
Discovery: laboratory research to develop the new
drug. Preclinical research with animal testing for
safety (Phase I). Clinical research on human subjects
Drug development
for medication safety (Phase II). Clinical research in
process involves these
humans comparing the new drug to accepted
steps according to the
medications placebo depending on the study
FDA:
(Phase III). FDA review of the results to determine
approval. Post marketing study to identify adverse
effects not found in earlier clinical studies (Phase IV)
The Institute for Safe Medication Practices (ISMP)
The Institute of Medicine (IOM) The Joint
2. Medication safety Commission The National Coordinating Council for
organizations Medication Error Reporting and Prevention (NCC
MERP) Food and Drug Administration (FDA) Safe
Use Initiative
Two basic type of ADRS: pharmacological and idiosyncratic.
85% to 90% of ADRS are pharmacological.
frequently occur in a hospital or nursing home
Adverse drug reactions
setting, and include medication errors, adverse drug
are usually preventable,
effects, and allergic idiosyncratic type reactions.
ADRS are not commonly the FDA does not mandate that ADRS be reported.
reported;
involves using multiple health care providers for
Polypharmacy care, using multiple medications, and using several
pharmacies prescription filling.
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