MICB 212 Final Exam Study Guide
Solutions
Main reservoir of Influenza - ANSWERBIRDS!
Main reservoir of Poliovirus - ANSWERHUMANS!
Targets of Anti-Viral Drugs in HIV - ANSWER1. Protease Inhibitor
2. RT Inhibitor
3. Integrase Inhibitory
4. Entry Inhibitor
there is no such thing called exit in...
3. HIV - ANSWER✔✔1. Poliovirus: (+) ssRNA + naked virus
2. Influenza: 8 segments of (-) RNA, enveloped
3. HIV: 2 identical copies of (+)ssRNA, enveloped
Reason why influenza vaccines need to be administered each year - ANSWER✔✔- frequent mutations
and gene arrangements in viral envelope protein genes -> Ab from previous vaccine won't work
- due to antigenic drift (minor) + shift (endemic)
Why is the dsDNA product from reverse transcribing HIV's +RNA during RT longer in length? -
ANSWER✔✔- due to RT process
- RT reads primer and terminator sequence on RNA and transcribes those as well onto DNA
3 Functions of Reverse Transcriptase (RT enzyme) in HIV replication cycle - ANSWER✔✔1. RDDP (RNA
dependent DNA pol) -> reads (+)ssRNA and makes ssDNA
2, RNAse H -> degrades RNA in RNA:DNA hybrid
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