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PHM 350 EXAM 1 SUMMER 2024 RATED A+
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PHM 350 EXAM 1 SUMMER 2024 RATED A+
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PHM 350 EXAM 1 SUMMER 2024 RATED A+All of the following routes of administration are classified as parenteral except:
A. Sublingual
B. Subcutaneous
C. Transdermal
D. Intramuscular
E. Intravenous Answer - A. Sublingual
In consideration of production of a particular effect, Drug X, Drug Y, and Drug Z
are effective. For this therapeutic effect, the ED50 of Drug X is 0.01 mg, the
ED50 of Drug Y is 1 mg, and the ED50 of Drug Z is 100 mg. Based on this
information, you can conclude that:
A. Drug Z should not be used to produce this therapeutic effect
B. BOTH Drug X is the most potent of the three drugs in terms of producing this
therapeutic effect AND Drug X is the safest of the three drugs
C. Drug X is the safest of the three drugs
D. Drug X is an agonist
E. Drug X is the most potent of the three drugs in terms of producing this
therapeutic effect Answer - E. Drug X is the most potent of the three drugs in
terms of producing this therapeutic effect
When two drugs, Drug A and Drug B, which are both substrates for the same
drug- metabolizing enzyme, are present:
A. The change of rate of metabolism of Drug A (compared to the rate of
metabolism when only Drug A is present) depends on the affinity of Drug B and
of Drug A for the enzyme
, B. There is no effect on the rate of metabolism of these drugs
C. The rate of metabolism of both drugs is increased (compared to the rate of
metabolism when only one drug is present)
D. The rate of metabolism of the drugs will only change if their metabolism
follows zero order kinetics
E. A and C, above Answer - A. The change of rate of metabolism of Drug A
(compared to the rate of metabolism when only Drug A is present) depends on
the affinity of Drug B and of Drug A for the enzyme
The mean plasma concentration of a drug repeatedly administered at the same
dosewith a constant interval between each consecutive dose:
A. Is the sum of the dose rate (g/min) and the clearance volume rate (ml/min)
of the administered drug
B. Is the ratio of the dose rate (g/min) to the clearance volume rate (ml/min) of
the administered drug
C. Is the product of the dose rate (g/min) and the clearance volume rate
(ml/min) of the administered drug
D. Will be insufficient to produce a continuous therapeutic effect
E. Is independent of the rate of elimination of the drug (for any given plasma
drug concentration) Answer - B. Is the ratio of the dose rate (g/min) to the
clearance volume rate (ml/min) of the administered drug
The half-life of drug X, eliminated according to first order kinetics, is 75minutes.
Drug X is administered by intravenous injection. Some time after injection, at a
time designated 0minute, the concentration of drug X was 500mg/ml. After
3hours 45minutes, the concentration of drug X will be:
A. 500mg/ml
B. 250mg/ml
C. 125mg/ml
D. 62.5mg/ml
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