receptor) in the brain and spinal chord *each bond to a different site on the
chloride channel8
- the result is an increase of inhibition and dampening a neuronal response
- there enhance the inhibitority effect of GABA
Drugs that bind to the chloride channels: Benzodiazepines - ✔✔
Benzodiazepines- MOA - ✔✔activation of benzodiazepine receptor
increases the frequency of opening the chloride channel
Benzodiazepines- routes of administration - ✔✔-usually capsule or tablet
Benzodiazepines- lethality - ✔✔commonly involved with overdose (deaths
from OD are rare)
- death has occurred after large doses
Benzodiazepines- pharmacology - ✔✔- high therapeutic index
- anti-anxiety effects
- decrease aggression
- produce minimal suppression of REM sleep
- relax muscles
- anti-convlusant action
- an antidote exists in case of OD
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