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PHAR 100 Exam Questions with 100% Correct Answers | Latest Version (2024/2025) Expert Verified
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PHAR 100 Exam Questions with 100% Correct Answers | Latest Version (2024/2025) Expert Verified
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PHAR 100 Exam Questions with 100% CorrectAnswers | Latest Version (2024/2025) Expert
Verified
Whichioneiofitheifollowingistatementsicorrectlyimatchesitheiscientistiwi
thitheiridrugidiscovery?
a.iPauliEhrlichidesignediorganoarsenicals,iwhichiselectivelyibounditoipa
rasites,ileadingitoiaicureiforisyphilis.
b.iStreptomyciniwasiintroducediforitheitreatmentiofituberculosisibyiAle
xanderiFleming.
c.iDomagkidiscovereditheifirstiantibiotic,ipenicillin,iduringitheiFirstiWorl
diWar.
d.iSulfaidrugsiwereiintroducediintoitherapyibyiWaksmanitoitreatibacteri
alidiseai-iCorrectiAnswer-
a.iPauliEhrlichidesignediorganoarsenicals,iwhichiselectivelyibounditoipa
rasites,ileadingitoiaicureiforisyphilis.
Theisoundiandilong-
establishediwayitoiproveioridisproveitheivalueiofiainewimedicationioritr
eatmentiisiaicontrolledistudy.iThisiincludes:
,a.iPatientsiareiselectediandiassigneditoivariousitestigroupsibasedionithei
richaracteristics.
b.iAllipatientsireceiveitheinewidrugioritheicontrolidrugi(gold-
standardioriplacebo),ionialternatingidays.
c.iTheipeopleiwhoiadministeritheidrugsidoinotiknowiwhoiisireceivingithei
newidrugioritheicontrolidrug.
d.iTheioutcomesimeasuredishouldipreferablyibeisubjectivei-
iCorrectiAnswer-
c.iTheipeopleiwhoiadministeritheidrugsidoinotiknowiwhoiisireceivingithei
newidrugioritheicontrolidrug.
.
DrugiAicanionlyirelieveipainiofimildiintensity.iDrugiB,ionitheiotherihand,ir
elievesipainiofiveryimarkediintensity.iFromithisiinformation,ioneicanicon
cludeithat:
a)iDrugiAihasigreateriefficacyithaniDrugiB.
b)iDrugiBihasigreateriefficacyithaniDrugiA.
c)iDrugiAiisimoreipotentithaniDrugiB.
,d)iDrugiBiisimoreipotentithaniDrugi-iCorrectiAnswer-
b)iDrugiBihasigreateriefficacyithaniDrugiA.
Theitherapeuticirangeiisibestidescribedias?
a.iTheimaximumipharmacologicaliresponseithaticanibeiproducedibyiaisp
ecificidrugiinithatibiologicalisystem.
b.iTheidoseioriconcentrationiofiaidrugithatiisirequireditoiproduceiairespo
nseiofiaicertainimagnitude,iusuallyi50%iofitheimaximaliresponseiforithati
drug.
c.iTheidoseithatiisiappropriateitoitreatimostiindividuals.
d.iTheirangeiofiplasmaiconcentrationsiwhereitheidrugiisieffectiveibutitox
icitiesiusuallyidoinotioccuri-iCorrectiAnswer-
d.iTheirangeiofiplasmaiconcentrationsiwhereitheidrugiisieffectiveibutitox
icitiesiusuallyidoinotioccur
Theiultra-shortidurationiofiactioniofithiopentaliisidueito:
a.iRedistributioniofitheidrugifromitheibrainitoimuscleiandifat.
, b.iRapidibreakdowniinitheiliver.
c.iPooripenetrationiintoitheibrain.
d.iRapidiexcretionibyitheikidneyi-iCorrectiAnswer-
a.iRedistributioniofitheidrugifromitheibrainitoimuscleiandifat.
Penicillinihasitheiabilityitoicombineiwithiproteinsitoiformiantigens,iandia
ismallipercentageiofitheipopulationireceivingipenicilliniexperienceiadver
seieffects.iTheseiadverseieffectsiareiproperlyiclassifiedias:
a.iAniextensioniofitheitherapeuticieffect.
b.iTeratogenesis.
c.iAidrugiallergy.
d.iDrugiaddictioni-iCorrectiAnswer-c.iAidrugiallergy.
TheiTD50iofiaidrugiiniratsiwasifounditoibei50imilligrams/kilogram.iTheiE
D50iofitheisameidrugiiniratsiwasi1imilligram/kilogram.iFromithisiinform
ation,ioneicanicalculateithatitheitherapeuticiindexiofitheidrugiiniratsiis:
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