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PHSC 3802 Hypertension Pathophysiology and Pharmacology questions with answers
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PHSC 3802 Hypertension Pathophysiology and Pharmacology questions with answers
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PHSC 3802 HypertensionPathophysiology and Pharmacology
questions with answers
BLOOD PRESSURE - correct answer ✔✔
DRUGS THAT ACT ON RAAS - correct answer ✔✔ACEi, ARBs, renin inhibitors
Renin is secreted in response to... - correct answer ✔✔-Decreased renal artery BV
-Sympathetic activation
Angiotensin II causes... - correct answer ✔✔-Direct constriction of vessels → ↑PVR
-Secretion of aldosterone → ↑Na+ reabsorption → ↑BP
-Secretion of AVP → ↑H2O reabsorption → ↑BV
Three sites to block the action of angiotensin II - correct answer ✔✔-Renin (converts angiotensinogen to
angiotensin I)
-ACE (converts angiotensin I to angiotensin II)
-AT1R (angiotensin receptor)
summary of contraction in vascular smooth muscle - correct answer ✔✔
AT1R is __-coupled - correct answer ✔✔Gq
ACE inhibitors end in... - correct answer ✔✔-pril
Three main ACEi classes - correct answer ✔✔-Sulfhydryl-containing agents, e.g., captopril
, -Dicarboxylate-containing agents, e.g., lisinopril, enalapril
-Phosphonate-containing agents, e.g., fosinopril
captopril: drug class - correct answer ✔✔Sulfhydryl-containing ACEi
Which drug is the only ACEi to cross the BBB? - correct answer ✔✔captopril
captopril: indications - correct answer ✔✔hypertension, heart failure
True/False: captopril is a pro-drug - correct answer ✔✔False; this is why captopril has a rapid onset of
action compared to pro-drug ACEi's
Why does captopril have a metallic taste? - correct answer ✔✔-SH group
enalapril: drug class - correct answer ✔✔dicarboxylate-containing ACEi
True/False: enalapril is a pro-drug - correct answer ✔✔True; active metabolite is enalaprilat
enalapril: indications - correct answer ✔✔hypertension, heart failure, left ventricular dysfunction
Why was enalapril developed? - correct answer ✔✔Remove the -SH of captopril
lisinopril: drug class - correct answer ✔✔second generation dicarboxylate-containing ACEi
True/False: lisinopril is a pro-drug - correct answer ✔✔False; lysine analogue of enalapril
lisinopril: indications - correct answer ✔✔hypertension, heart failure, used after acute MI and for
diabetic nephropathy
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