Exam (elaborations)
BMTCN EXAM QUESTIONS AND ANSWERS
- Course
- Institution
BMTCN EXAM QUESTIONS AND ANSWERS
[Show more]
Content preview
BMTCN EXAM QUESTIONS AND ANSWERSWhat type of transplants commonly have PTLD as a secondary malignancy? -
Answers- Allo HSCT with T-cell depleted graft
Therapies associated with therapy-related acute leukemia and MDS - Answers-
alkylating agents (eg. Cytoxan, cisplatin, melphalan, busulfan, ifos) , radiation,
topoisomerase II inhibitors (eg. doxorubicin, etoposide, mitoxantrone)
Genetic predispositions that increase risk of primary and secondary cancers - Answers-
neurofibromatosis type 1, Fanconi anemia
Risk factors for PTLD - Answers- T-cell depleted graft, mismatched related or unrelated
donor.
Busulfan, ATG, mAbs, TBI
patient w/ primary immunodeficiency, acute or extensive GVHD, EBV
Risk factors for secondary solid tumors - Answers- younger age at HSCT, TBI, chronic
GVHD, increasing time from transplant, infections, genetic predisposition, lifestyle
factors
Treatment options for PTLD - Answers- EBV-specific cytotoxic T cells, mAbs targeted to
B cells (rituximab), combination chemotherapy
Treatment options for secondary MDS/acute leukemia - Answers- conventional chemo
or allo transplant. Poor outcomes.
QOL domains - Answers- Physical, Functional, Psychological, Social,
Spiritual/existential, Multiple interactions between domains
Altered sexual health in male HSCT survivors - Answers- damage to the hypothalamic-
pituitary-gonadal axis: elevated FSH, elevated LH, low testosterone levels; cavernosal
arterial insufficiency causing ED
Altered sexual health in female HSCT survivors - Answers- alkylating agents and
radiation cause infertility and premature ovarian failure, elevated FSH and LG, low
estradiol, menopausal symptoms
Risk factors for vaginal alterations post transplant - Answers- POF (premature ovarian
failure), TBI, chronic GVHD
Risk factors for infertility - Answers- pre-HSCT antineoplastic therapy, exposure to
alkylating agents, TBI or pelvic irradiation, older age
, Pregnancy risks in HSCT survivors - Answers- increased risk of preterm birth and low
birth weight, cardiac decompensation during pregnancy 2/2 prior anthracycline
exposure. Similar rate of spontaneous abortion to general population.
Recommended vaccines - Answers- Pneumococcal, Diptheria-tetanus, Pertussis,
Meningococcal, Inactivated polio
Hep B, Recombinant Hep A, Influenza, Measles Mumps and Rubells, HPV
When can HSCT survivors get vaccines? - Answers- inactive vaccines start at 6 months
post HSCT, live vaccines start at 2 years post HSCT (in absence of ongoing
immunosuppression and GVHD)
Most common secondary malignancy in pediatric patients who received radiatios? -
Answers- Nonsquamous call carcinoma
Interventions/treatment for vaginal chronic GVHD - Answers- topical steroids, topical
cyclosporine, vaginal dilation
Prevention of vaginal chronic GVHD - Answers- patient education, topical estrogen,
early initiation of HRT, vaginal dilation in absence of sexual activity, regular gyn exams
Side effects of ovarian failure in prepubescent females - Answers- infertility, impaired
sexual development, short stature
Marker that shows immune recovery - Answers- CD4
Myeloid progenitor cell mature into: - Answers- Megakaryocytes (produce plts),
Erythrocytes, Mast cells, Myeloblasts, neutropils, basophils, macrophages, monocytes,
erythrocyte, eosinophils, myeloid dendritic cells, tissue mast cell
Lymphoid progenitor cells mature into: - Answers- NK cells, small lymphocytes, which
differentiate into B cells and T cells
innate immunity - Answers- occurs naturally, uses phagocytes that release
inflammatory mediators and NK cells
acquired immunity - Answers- response of either B cells or T cells to antigens
Syngeneic transplant - Answers- Identical twin source. No need for
immunosuppression. No graft-versus-tumor effect
Matched sibling/related transplant - Answers- HLA-identical relative. No potential stem
cell contamination. Continued access to cells. Only 25% of population has a sibling
match. Risk of GVHD.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller GEEKA. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
82871 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now