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PHMY 610 HERPESVIRIDAE PART 2 EXAM QUESTIONS AND ANSWERS
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PHMY 610 HERPESVIRIDAE PART 2 EXAM QUESTIONS AND ANSWERS...
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PHMY 610 HERPESVIRIDAE PART 2 EXAMQUESTIONS AND ANSWERS
VZV causes both clinical ________ as initial presentation and _______
infection as latent reactivation
chicken pox, shingles
what is the transmission of VZV
respiratory droplets or direct skin-to-skin contact with vesicles
T/F: VZV initially infects fibroblasts, remains latent in nerve cells
true
what is the incubation period of VZV
14-21 days (very long, delay between exposure and infection)
what are the stages of chickenpox
-Fever, itching, generalized flu-like symptoms for ~2 days before rash
-Infectious (~7 days) stage 1 (papule) & stage 2 (blister) then to non-infectious
stage 3 (scabbing)
when is chickenpox no longer infectious
When the last lesion crusts over
T/F; chickenpox in children typically mild vesicular rash with limited
complications but fever is typical for 1-2 days at initial infection
true
what are two high risk groups with chickenpox
IC child and pregnancy
is chickenpox in children typically self limiting
yes - symptomatic care
is chickenpox more severe in adults or children typically
, adults
chickenpox during 1st trimester = ??
fetal varicella syndrome
chickenpox during 2nd/3rd trimester = ??
· zoster at early age and/or chickenpox as newborn
T/F: immunoglobulin treatment available for chickenpox (varicella)
true
what is prevention of varicella
varicella vaccine - live, attenuated vaccines
VZV move up peripheral nerve for latent viral DNA to sit in nerve cell in ???
dorsal root ganglion
what does VZV reactivate due to
some trigger such as IC state or stress
what are some risk factors for herpes zoster
> 50 years, trauma, IC, CLD or CKD, stress
how long does shingles last
2-4 weeks
T/F: herpes zoster often has dermatomic distribution
true
what are some complications of herpes zoster
post herpetic pain, eye complications, ramsey hunt syndrome (ear
inflammation/deafness/balance effects), vasculopathy
what dermatomic distribution = more severe
cross midline
T/F: 1.78x more likely to have stroke in 1st month following zoster infection
(slightly decreases as 1 year following zoster infection)
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