UNIT 9 MN 553 Pharm Exam With Complete Solutions

UNIT 9 MN 553 Pharm Exam With
Complete Solutions

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:



Question options:



A The necessity of monitoring drugs metabolized by 2D6 for toxicity



Higher doses required of drugs metabolized by 2D6, including the selective serotonin
reuptake inhibitors



Reduced conversion of codeine to morphine by CYP 2D6



The need for decreased dosages of medications, including beta blockers - ANSWER
Increased dosages needed of medications metabolized by 2D6, including the selective
serotonin reuptake inhibitors



Rifampin is a nonspecific inducer of CYP450 that can:

Related Questions:



Cause toxicity of rifampin and should be carefully monitored



Cause toxicity of medications, like oral contraceptives, when taken concomitantly



Induce the metabolism of medications, like oral contraceptives, leading to therapeutic
failure

, Cause nonspecific changes in drug metabolism - ANSWER Induce the metabolism of
drugs, such as oral contraceptives, leading to therapeutic failure



Inhibition of P-glycoprotein by a drug such as quinidine may lead to:

Question options:



Decreased therapeutic levels of quinidine



Increased therapeutic levels of quinidine



Decreased levels of a coadministered drug, such as digoxin, that requires
P-glycoprotein for absorption and elimination



Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein
for absorption and elimination - ANSWER Increased levels of a coadministered drug,
such as digoxin, that requires P-glycoprotein for absorption and elimination



Warfarin resistance in patients with VCORC1 mutation may result in:

Question options:



Toxic levels of warfarin building up



Decreased response to warfarin



Increased risk for significant drug interactions with warfarin



Less risk of drug interactions with warfarin - ANSWER Decreased response to warfarin