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MRCP Official Sample Questions And Answers Latest Top Score. A 65-year-old woman presented with a 12-hour history of the sudden onset of gait unsteadiness, vomiting and headache, followed by increasing drowsiness. What is the most likely diagnosis? A: acute cerebell...

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  • November 4, 2024
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MRCP Official Sample Questions And
Answers Latest Top Score.


A 65-year-old woman presented with a 12-hour history of the sudden onset of gait
unsteadiness, vomiting and headache, followed by increasing drowsiness.

What is the most likely diagnosis?

A: acute cerebellar haemorrhage

B: acute subdural haemorrhage

C: frontal subdural empyema

D: herpes simplex encephalitis

E: pituitary apoplexy - correct answer. A

A post-marketing observational study of a new drug was conducted on 5000 patients
following clinical trials.

What best describes the data generated from this type of study?


A: comparative efficacy

B: cost-benefit

C: cost effectiveness

D: potency

E: profile of adverse effects - correct answer. E

A 79-year-old woman was admitted for elective hip replacement surgery. On
examination, she was pale. There was 2-cm splenomegaly and there were small
discrete axillary lymph nodes.

haemoglobin 107 g/L (115-165)

,white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)

What is the most likely diagnosis?


A: acute myeloid leukaemia

B: chronic lymphocytic leukaemia

C: chronic myeloid leukaemia

D: myelodysplasia

E: myelofibrosis - correct answer. B

A 17-year-old boy presented with a non-blanching rash over his legs, a swollen knee
and painless, visible haematuria.

Urinalysis showed blood 3+, protein 1+.

serum creatinine 210 µmol/L (60-110) urine culture negative ultrasound scan of kidneys
normal

What glomerular abnormality is most likely to be present at renal biopsy?

A: focal segmental sclerosis

B: foot process fusion

C: linear deposition of IgG on the basement membrane

D: mesangial deposition of IgA

E: thickening of basement membranes - correct answer. D

A 75-year-old woman developed a spreading cellulitis on her left leg secondary to
ulceration.

blood cultures MRSA

In addition to vancomycin, what is the most appropriate antibiotic?

A: amoxicillin

B: azithromycin

,C: flucloxacillin

D: metronidazole

E: rifampicin - correct answer. E

A 45-year-old woman presented with right flank pain. She had a 4-year history of
hypertension and progressive cognitive impairment.

On examination, she had livedo reticularis and tenderness in the right flank. Her BP was
185/105 mmHg. Urinalysis showed blood 3+, protein 1+.

Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)

serum creatinine 106 µmol/L (60-110)

What antibody test is most likely to be positive?

A: anticardiolipin

B: anticentromere

C: anti-glomerular basement membrane

D: antimitochondrial

E: anti-neutrophil cytoplasmic

E: anti-neutrophil cytoplasmic - correct answer. A

A 37-year-old woman presented with a history of intermittent lightheadedness.
Examination was normal.ECG normal

24-hour ambulatory ECG tracing
atrial and ventricular premature beats; nocturnal bradycardia and Mobitz type 1
atrioventricular block, and supraventricular tachycardia

Which abnormality on the 24-hour ambulatory ECG is clinically most important?

A: atrial premature beats

B: profound sleep-associated bradycardia

C: supraventricular tachycardia

, D: transient Mobitz type 1 atrioventricular block

E: ventricular premature beats

E: ventricular premature beats - correct answer. C

A 28-year-old man presented with a 1-month history of weight loss, abdominal
distension, flatulence and foul-smelling diarrhoea following a visit to India.

anti-tissue transglutaminase antibodies negative

stool cultures and microscopy negative

What is the most likely diagnosis?

A: acute HIV seroconversion illness

B: coeliac disease

C: giardiasis

D: hookworm infection (ancylostomiasis)

E: viral gastroenteritis - correct answer. C

A 30-year-old woman presented with a 6-month history of tremor and difficulty in
speaking.

On examination, she was found to have increased muscle tone in all four limbs,
bradykinesia and 4-cm hepatomegaly.

What laboratory finding would best support a diagnosis of Wilson's disease?

A: increased incorporation of radioactive copper into caeruloplasmin

B: low hepatic copper content

C: low serum caeruloplasmin concentration

D: low serum free copper concentration

E: low urine copper concentration - correct answer. C

Question 10

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