,1. Question: Which cytochrome P450 enzyme is primarily
responsible for the metabolism of warfarin?
- A) CYP1A2
- B) CYP2C9
- C) CYP3A4
- D) CYP2D6
Answer: B) CYP2C9
Rationale: Warfarin is primarily metabolized by CYP2C9, and
variations in this enzyme can significantly affect drug levels and
patient response.
, 3. Question: The mechanism of action of SGLT2 inhibitors in
treating type 2 diabetes involves:
- A) Increasing insulin sensitivity
- B) Inhibiting renal glucose reabsorption
- C) Stimulating insulin release from pancreatic beta cells
- D) Decreasing hepatic glucose production
Answer: B) Inhibiting renal glucose reabsorption
Rationale: SGLT2 inhibitors reduce blood sugar levels by
inhibiting glucose reabsorption in the kidneys, leading to increased
glucose excretion in the urine.
### Fill-in-the-Blank Questions
4. Question: _____ is a potential adverse effect of long-term
proton pump inhibitor use due to decreased calcium absorption.
Answer: Osteoporosis
Rationale: Long-term use of proton pump inhibitors can lead
to decreased gastric acidity, which may impair calcium absorption
and thus increase the risk of osteoporosis.
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