Maryville NURS 660 Exam 3 With Complete Solution
How do benzodiazepine help with anxiety? - correct answer - Benzodiazepine target GABA
neurotransmission via the PAM (positive allosteric modulation
Allodynia - correct answer - Pain due to a stimulus that does not normally provoke pain
Hyperalgesia - correct answer - Increased pain from a stimulus that normally provokes pain
Nocioceptive pain - correct answer - Pain that arises from actual or threatened damage to non-
neural tissue and is due to the aciviation of .....
Neuropathic pain - correct answer - Pain created by a lesion or disease of the somatosensory
nervous system
Central Sensitization - correct answer - Increased responsiveness of nocioceptive neurons in
the CNS to their normal or subthreshold afferent input.
Nocioceptor - correct answer - A primary afferent (sensory) neuron that is only activated by a
noxious stimulus
Nocioception - correct answer - The process by which a nocioceptor detects a noxious stimulus
and generates a signal (action potentials) that is propagated towards higher centers in the
nocioceptive pathway
Dorsal Root Ganglion (DRG) - correct answer - Contains the cell bodies of primary afferent
neurons, proteins, including transmitters, receptors, and structural proteins, are synthesized
here and transported to peripheral and central terminals.
Interneurons - correct answer - Neuron in the dorsal horn that receives input from PANS and/
or interneurons, and projects up the spinal cord to higher processing centers
Spinothalamic tract - correct answer - tract of neurons that project from the spinal cord to the
thalamus
Spinobulbar tracts - correct answer - Several different tracts of neurons that project from the
spinal cord to brainstem nuclei
Somatosensory cortex - correct answer - Region of the cerebral cortex that receives input
mainly from cutaneous sensory nerves; the cortex is topographically arranged, with adjacent
areas receiving input from adjacent body areas; stimulation of the somatosensory cortex
creates sensations from the body part that projects to it.
A-Beta fibers - correct answer - detect small movements, light touch
A-Delta fibers - correct answer - sense noxious mechanical stimuli and subnoxious
thermalstimuli
C-fibers - correct answer - bare nerve endings that are only activated by noxious mechanical,
thermal, or chemical stimuli
, Maryville NURS 660 Exam 3 With Complete Solution
Describe Neuropathic Pain - correct answer - pain that arises from damage to, or dysfunction
of, any part of the peripheral or central nervous system
Describe normal pain - correct answer - pain caused by activation of nociceptive nerve fibers
What is Peripheral Nociceptive Pain due to? - correct answer - Inflammation or mechanical
damage in tissues
What does Peripheral Nociceptive pain respond to - correct answer - NSAIDS, opioids,
procedures
Give examples of peripheral nociceptive pain - correct answer - Osteoarthritis, Rheumatoid
arthritis, Cancer pain
What is peripheral neuropathic pain due to? - correct answer - Damage to, or dysfunction of,
peripheral nerves
What does peripheral neuropathic pain respond to? - correct answer - both peripheral and
centrally acting pharmacologic therapies
Give examples of peripheral neuropathic pain - correct answer - Diabetic neuropathic pain,
postherpetic neuralgia,
What is central neuropathic pain or central sensitization due to? - correct answer - central
disturbance in pain processing (diffuse hyperalgesia/ allodynia
What does central neuropathic pain or central sensitization respond to? - correct answer -
neuroactive compounds that alter levels of neurotransmitters involved in pain transmission,
and responsive to nonpharmacologic therapies such as exercise and CBT
What are examples of central neuropathic pain/ central sensitization? - correct answer -
Fibromyalgia, IBS, TMJD, Tension headache
What is the combination of peripheral and central mechanism pain due to? - correct answer -
involvement of both inflammatory or mechanical damage to the tissues along with dysfunction
in central pain processing
How to treat a combination of peripheral and central mechanism-related pain - correct answer
- need to treat all contributing mechanisms
Give examples of combination of peripheral/ central mechanism pain - correct answer - low
back pain, Rheumatologic diseases that develop into comorbid fibromyalgia
List the Benzodiazepine Anxiolytics - correct answer - Xanax, Valium, Ativan
List the labs for Benzodiazepine Anxiolytics - correct answer - Monitor levels of TCA and Dig
with concurrent use of Benzos--may increase those levels. Long term: check liver and CBC
periodically.
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