Exam (elaborations)
Maryville Nurs 660 Exam 3
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Maryville Nurs 660 Exam 3How do benzodiazepine help with anxiety? - ANS Benzodiazepine target GABA neurotransmission via
the PAM (positive allosteric modulation
Allodynia - ANS Pain due to a stimulus that does not normally provoke pain
Hyperalgesia - ANS Increased pain from a stimulus that normally provokes pain
Nocioceptive pain - ANS Pain that arises from actual or threatened damage to non-neural tissue and is
due to the aciviation of .....
Neuropathic pain - ANS Pain created by a lesion or disease of the somatosensory nervous system
Central Sensitization - ANS Increased responsiveness of nocioceptive neurons in the CNS to their normal
or subthreshold afferent input.
Nocioceptor - ANS A primary afferent (sensory) neuron that is only activated by a noxious stimulus
Nocioception - ANS The process by which a nocioceptor detects a noxious stimulus and generates a
signal (action potentials) that is propagated towards higher centers in the nocioceptive pathway
Dorsal Root Ganglion (DRG) - ANS Contains the cell bodies of primary afferent neurons, proteins,
including transmitters, receptors, and structural proteins, are synthesized here and transported to
peripheral and central terminals.
Interneurons - ANS Neuron in the dorsal horn that receives input from PANS and/ or interneurons, and
projects up the spinal cord to higher processing centers
, Spinothalamic tract - ANS tract of neurons that project from the spinal cord to the thalamus
Spinobulbar tracts - ANS Several different tracts of neurons that project from the spinal cord to
brainstem nuclei
Somatosensory cortex - ANS Region of the cerebral cortex that receives input mainly from cutaneous
sensory nerves; the cortex is topographically arranged, with adjacent areas receiving input from
adjacent body areas; stimulation of the somatosensory cortex creates sensations from the body part
that projects to it.
A-Beta fibers - ANS detect small movements, light touch
A-Delta fibers - ANS sense noxious mechanical stimuli and subnoxious thermalstimuli
C-fibers - ANS bare nerve endings that are only activated by noxious mechanical, thermal, or chemical
stimuli
Describe Neuropathic Pain - ANS pain that arises from damage to, or dysfunction of, any part of the
peripheral or central nervous system
Describe normal pain - ANS pain caused by activation of nociceptive nerve fibers
What is Peripheral Nociceptive Pain due to? - ANS Inflammation or mechanical damage in tissues
What does Peripheral Nociceptive pain respond to - ANS NSAIDS, opioids, procedures
Give examples of peripheral nociceptive pain - ANS Osteoarthritis, Rheumatoid arthritis, Cancer pain
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