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ACBS 419 questions and correct answers rated A+ $17.99   Add to cart

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ACBS 419 questions and correct answers rated A+

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ACBS 419 questions and correct answers rated A+

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  • November 11, 2024
  • 16
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • ACBS
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BravelRadon
ACBS 419 questions and correct
answers rated A+

what complement peptide is cleaved by CD46? - correct answer ✔✔C3b (and C4b)



What is Not an activity of complement? - correct answer ✔✔Activation of T cells



What cell is the bridge between innate and adaptive immune system? - correct answer ✔✔dendritic cell



what cell secrete mucus, a part of the innate immunity? - correct answer ✔✔goblet cells



what is the C3-C5 convertase? - correct answer ✔✔C4b2a3b



chemokine give the immune system information about what? - correct answer ✔✔where a pathogen is



IRAK4 deficiency is seen in one of the case studies, what signaling pathway is disrupted by this
deficiency? - correct answer ✔✔MyD88 signaling



this cell is involved in bactericidal mechanisms and antigen presentation in the periphery? - correct
answer ✔✔macrophages



what region of the antibody contains the antigen binding site? - correct answer ✔✔variable light chain



during negative selection of B cells in the bone marrow, what will happen if the B cell binds self-antigen?
- correct answer ✔✔it dies via apoptosis



what is NOT a function of antibodies? - correct answer ✔✔disposal of red blood cells (the spleen does
this)

,where fo T cells originate? - correct answer ✔✔bone marrow but develop in thymus



what cell does NOT express MHC class 2 on its surface? - correct answer ✔✔neutrophil



what cells do NOT posses MHC class 1 on their surface? - correct answer ✔✔they all do (basically all cells
produce MHC class 1 and B cells have both)



CD4 helper T cells bind to which MHC class? - correct answer ✔✔MHC class 2



what do CD8 cytotoxic T cells do? - correct answer ✔✔kill



what is lysozyme an example of? - correct answer ✔✔antimicrobial peptide



what is the function of the proteasome? - correct answer ✔✔degrades proteins



what recognizes PAMPs? - correct answer ✔✔Toll-like receptors (TLRs)



where does negative selection occur for T cells? - correct answer ✔✔thymus (undergo positive and
negative selection in thymus)



what do lysosomes do? - correct answer ✔✔kill gram positive bacteria by cleaning NAM-NAG bond
(cannot kill gram negative bacteria)



what does B1 defensin do? - correct answer ✔✔makes a pore in the bacteria membrane causing lysis



what is RegIII-alphas activity and what type of bacteria are resistant to it? - correct answer ✔✔forms a
pore in the membrane, gram negative bacteria



what do panted cells secrete and to where? - correct answer ✔✔AMP's; mucus

, what are transcriptional levels regulated by in terms of the innate immune response? - correct answer
✔✔PAMP concentration



how does the classical pathway begin? - correct answer ✔✔C1q binds to the bound IgM molecule



what molecule binds to the antigens directly on bacterial surfaces? - correct answer ✔✔B cells (light and
heavy chains bind)



what cleaves C3 into C3a and C3b? - correct answer ✔✔C4b2a



what is C4b's function? - correct answer ✔✔covalently bind pathogen and aids in phagocytosis (helps in
opsonization)



what are the three anaphyltoxins? - correct answer ✔✔C3a, C5a, and C2b



what is C8's function? - correct answer ✔✔binds C5b67 and initiates C9 polymerization



cytokine binding ____ leads to phosphorylation of ____ - correct answer ✔✔Jack cytokine receptor;
STAT (in the MyD88 cascade)



what is phosp-STATs function? - correct answer ✔✔migrates to nucleus and alters transcription of genes
(in MyD88 pathway)



what binds adhesion molecules on vascular endothelium near sites of infection, thus receiving cytokine
signaling? - correct answer ✔✔monocytes



what local effect of IL-1-beta? - correct answer ✔✔activates endothelium and lymphocytes, local tissue
destruction



what is the systemic effect of TNF-alpha? - correct answer ✔✔fever, shock, inflammation

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