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Advanced Pathophysiology HESI review Study Guide.

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  • Pathophysiology

Advanced Pathophysiology HESI review Study Guide. Metabolic acidosis - answerlow pH, low HCO3 metabolic alkalosis - answerhigh pH, high HCO3 respiratory acidosis - answerlow pH, high CO2 respiratory alkalosis - answerhigh pH, low CO2 metabolic acidosis causes - answerPrimary Cause: Addition o...

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  • November 12, 2024
  • 13
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • Pathophysiology
  • Pathophysiology
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©THEBRIGHT EXAM SOLUTIONS

11/05/2024 12:06 PM



Advanced Pathophysiology HESI review
Study Guide.


Metabolic acidosis - answer✔low pH, low HCO3

metabolic alkalosis - answer✔high pH, high HCO3

respiratory acidosis - answer✔low pH, high CO2

respiratory alkalosis - answer✔high pH, low CO2

metabolic acidosis causes - answer✔Primary Cause: Addition of large amounts of fixed acids to body
fluids; Contributing Causes: Lactic acidosis (circulatory failure), Ketoacidosis (diabetes, starvation),
Phosphates and sulfates (Renal dz), Acid ingestion (salicylates), Secondary to respiratory alkalosis,
Adrenal insufficiency

metabolic alkalosis causes - answer✔Primary Cause: Retention of base or removal of acid from body
fluids; Contributing Causes: Excessive gastric drainage, Vomiting, Potassium depletion (diuretic therapy),
Burns, Excessive Sodium Bicarb admin

respiratory acidosis causes - answer✔Primary Cause: Hypoventilation (causes hypercapnia);
Contributing Causes: COPD, Pulmonary dz, Drugs, Obesity, Mechanical asphyxia, Sleep Apnea

respiratory alkalosis causes - answer✔• Primary stimulation of CNS: hyperventilation. Can be due to
emotional origin (anxiety, fear, apprehension), CNS infection (encephalitis), or salicylate poisoning.

• Reflex stimulation of CNS. Hypoxia stimulates hyperventilation (heart failure, pneumonia, pulmonary
emboli).

Can also be stimulated by fever.

• Mechanical hyperventilation, resulting in "over breathing."

Neuro exams include: - answer✔-hand strength, limb strength

-ability to follow commands

-ability to move eyes in equal and uniform fashion

-deep pain stimulus response

, ©THEBRIGHT EXAM SOLUTIONS

11/05/2024 12:06 PM

-symmetrical and coordinated movement

-clear, speech.

Acute Bronchitis patho - answer✔infection or inflammation of the bronchi. In more than 90% of
individuals, this is a self-limiting disorder caused by viruses.

will not have high fevers and will have only scattered coarse wheezes on examination without evidence
of pulmonary consolidation.

Chest X-ray examination is usually normal.

Chronic Bronchitis patho sequence - answer✔The chronic bronchitis pathophysiologic sequence of
events is as follows:



Hypersecretion of bronchial mucus, which leads to

Recurrent respiratory infections, which lead to

Airway inflammation, which leads to

Bronchospasm and irreversible airway obstruction

chronic bronchitis patho - answer✔characterized by chronic inflammation with recruitment of
neutrophils, macrophages, and lymphocytes to the lung, with progressive damage to airways and the
lung parenchyma.



hyperplasia of the mucus-producing goblet cells of the bronchial epithelium occurs, resulting in the
production of large amounts of mucus in the airways.



Mucus accumulation facilitates the colonization and growth of bacteria, which further contributes to
airway inflammation, bronchospasm, and eventual scarring.



Narrowed airways cause v/q mismatching and expiratory airway obstruction with air trapping, resulting
in both hypoxemia and hypercapnia.

CAD risk factors pathological - answer✔Major:

Advanced age

Gender (men > women before age 55, women > men after age 55)

Dyslipidemia

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