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BMD430 L8 The MHC and Antigen Presentation Exam Practice Questions and Answers 100% Pass $11.49   Add to cart

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BMD430 L8 The MHC and Antigen Presentation Exam Practice Questions and Answers 100% Pass

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BMD430 L8 The MHC and Antigen Presentation Exam Practice Questions and Answers 100% Pass What are the three functions of the innate immune system? - ANSWER-1. Physical and Chemical Barriers to Infection 2. Cellular Responses to Infection 3. Activation of Adaptive Immune System Why is the MHC ...

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  • November 12, 2024
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EmilyCharlene
BMD430 L8 The MHC and Antigen Presentation
Exam Practice Questions and Answers 100% Pass


What are the three functions of the innate immune system? - ANSWER✔✔-1. Physical

and Chemical Barriers to Infection


2. Cellular Responses to Infection


3. Activation of Adaptive Immune System


Why is the MHC necessary? - ANSWER✔✔-For the activation of T cells


What are the similarities and differences between the BCR and TCR (particularly as

they related to the MHC?) - ANSWER✔✔-Similarities:


- Both have heavy and light chains


- Both have variable and constant regions


- Both have hypervariable regions


- Both have similar functions in antigen recognition




Differences:


- Their general shape (BCR is Y-shaped, TCR is rectangular shaped)

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, - **Recognition mechanism (BCR can recognize free-floating antigen, TCR require

antigen to be bound to MHC) (**MAIN DIFFERENCE**)


- Consequences of activation (BCR activation leads to antibody secretion, TCR

activation does NOT lead to receptor secretion)


What is (self) MHC-restriction? - ANSWER✔✔-The TCR on T cells will interact with

MHC-peptide only if the MHC is of the same type as the one the T cells encountered in

the thymus during their selection process (only your T cells can recognize your MHC

molecules)


On which cell types are MHC molecules expressed? - ANSWER✔✔-MHC I: all

nucleated cells (so not on erythrocytes)


MHC II: antigen presenting cells (B cells, macrophages, dendritic cells)


On which cell types are TCRs expressed? (this isn't a trick question). - ANSWER✔✔--

CD8 Cytotoxic T cells


- CD4 Helper T cells


What does MHC stand for? - ANSWER✔✔-Major Histocompatability Complex


What are the components of the MHC II? - ANSWER✔✔-beta chain (B1, B2)


alpha chain (a1, a2)




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