Are carcinomas cancers of blood cells? - Answers No
3 characteristics of caretaker genes - Answers -BRCA1 is a caretaker gene
-Defective caretaker genes increase mutation rates in cells
-Caretaker genes repair or prevent DNA damages
3 mechanisms to convert a proto-oncogene to an oncogene - Answers -point mutation
-chromosomal translocation
-gene amplification
3 characteristics of the Philadelphia chromosome - Answers -Generated by chromosomal translocation
-Caused fusion of bcr and abl genes
-The fused protein exhibits uncontrolled kinase activity
When it comes to mouse p53 & DNA damage responses, DNA damage _____________ - Answers
induces p53 stabilization
Do stem cells have telomerase activity? - Answers Yes
Differentiated cells have ___ telomerase activity - Answers low
Most cancer cells have ___ telomerase activity - Answers high
Inhibiting telomerase activites may _______ - Answers inhibit cancer growth
3 ways abnormal activation of a receptor can happen in cancer cells: - Answers -virus-derived activator
protein induced receptor dimerization
-point mutation induced receptor dimerization
-fusion with another protein induced receptor dimerization
Hereditary cancers typically exhibit loss-of-heterozygosity in _____ - Answers tumor suppressor genes
What is Src? - Answers A kinase
A gain-in-function mutation in ___ will bypass restriction point controls - Answers cyclin D
Typical characteristics of "transformed" cells in culture: - Answers -loss of contact inhibition of growth
-form foci on a plate
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