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BME 409 Exam 3 Questions and Answers
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BME 409 Exam 3 Questions and Answers
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BME 409 Exam 3 Questions andAnswers
Tank Treading - Answer-Membrane moves while RBC is tumbling (stress not applied to
same place on membrane)
Membrane moves at different rate than RBC tumbles
Hemolysis, Complete Rupture - Answer-Exposes Hb
Determined clinically by measuring plasma free Hb (pfHb)
Hemolysis, Sublethal Damage - Answer-6% strain before RBC rupture
~ 200 ms to relax (repeated strain will not allow relaxation)
Micropores allow Hb to leak out
Results in decreased deformabiliity, decreased ability to transfer oxygen, increased
aggregation
Difficult to pick up clinically, long-term consequence = organ failure
2 ways of measuring Hb - Answer-1) Direct spectroscopy
2) Chemical (assay)
Normalized Index of Hemolysis Typical Values - Answer-< 0.01 Blood pumps
< 0.02 Clinically accepted
< 0.04 Physiologically acceptable
> 0.06 pfHb (need transfusion at this point)
Platelet Lysis (Breaking) - Answer-Platelets activate before being damaged
Cannot use power law
No detectable lysis threshold
WBCs - Answer-Stress to cause damage: 75 dynes/cm^2
Regional (don't travel unless sick or have cancer), so we are not that concerned about
damage
Low numbers
Decreased phagocytosis
Von Willebrand Factor (vWF) - Answer-Protein, ball that unfurls that be ~ 1 mm long
Unfurling exposes proteins
When in ball, proteins are protected (along with clotting ability)
Destroyed by mechanical stress or enzymatic stress
This is new, a lot to learn
Womersley Model Asumptions - Answer-1. Unsteady flow
2. Incompressible
3. Newtonian fluid
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