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PHAR 100 Assessment Tools Exam Questions and Answers
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PHAR 100 Assessment Tools Exam Questions and Answers
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PHAR 100 Assessment Tools ExamQuestions and Answers
The ultra short duration of action of thiopental is due to:
a. Rapid breakdown in the liver
b. Rapid excretion by the lungs
c. Redistribution of the drug from the brain to muscle and fat
d. Rapid excretion by the kidney
e. Poor penetration into the brain - Answers -c. Redistribution of the drug from the brain
to muscle and fat
Which of the following statements is correct?
a. The generic name of a drug is a non-proprietary name
b. If a drug is marketed by more than one company, it may have several brand
(proprietary) names
c. Drug products made by different drug companies usually yield similar blood levels as
they are approved for market on the basis of producing similar blood levels to the name
brand product
d. For orally administered drugs, acting outside the gastrointestinal tract, it is only that
portion of the drug that goes into solution in the fluids of the stomach and intestine that
can be absorbed into the blood and exert an effect
e. All of the above - Answers -e. All of the above
Drug A can only relieve pain of mild intensity. Drug B, on the other hand, relieves pain
of very marked intensity. From this information, one can conclude that:
a. Drug A has greater efficacy than Drug B
b. Drug B has greater efficacy than Drug A
c. Drug A is more potent than Drug B
d. Drug B is more potent than Drug A
e. None of the above - Answers -b. Drug B has greater efficacy than Drug A
The TD50 of a drug in rats was found to be 50 milligrams/kilogram. The ED50 of the
same drug in rats was 1 milligram/kilogram. From this information, one can calculate
that the therapeutic index of the drug in rats is:
a. 49
b. 0.02
c. 51
,d. 500
e. 50 - Answers -e. 50
The reason for the selective toxicity of sulfanilamide is the following:
a. Susceptible bacteria require folic acid, while the hosts' cells do not
b. Susceptible bacteria synthesize folic acid from asparagine, while the hosts' cells use
preformed folic acid
c. Susceptible bacteria synthesize folic acid from para-aminobenzoic acid (PABA), while
the hosts' cells use preformed folic acid
d. Susceptible bacteria synthesize folic acid from atoxyl, while the hosts' cells use
preformed folic acid
e. Susceptible bacteria synthesize folic acid from para-aminobenzoic acid (PABA), while
the hosts' cells do not utilize folic acid - Answers -c. Susceptible bacteria synthesize
folic acid from paraaminobenzoic acid (PABA), while the hosts' cells use preformed folic
acid
Which one of the following statements is correct:
a. Drugs can be dissolved in non-purified water for intravenous injection
b. It is not possible for poisonous materials to be absorbed through the skin
c. Sometimes drugs are given rectally because it always provides the greatest
bioavailability of a drug
d. A good relationship exists between the concentration of drug in the blood and the
concentration of drug at the site of action
e. After injection of drugs into skeletal muscle, the drugs are generally slowly absorbed
into the blood supply of the muscle and usually act after a period of one hour - Answers
-d. A good relationship exists between the concentration of drug in the blood and the
concentration of drug at the site of action
Which one of the following statements is correct?
a. The main use of ergonovine today is to induce labour
b. Colchicine, isolated from the Colchium plant, is a valuable drug for the treatment of
rheumatoid arthritis
c. Morphine is extracted from the opium poppy and is the gold standard for pain relief
d. Ephedrine is isolated from the calabar bean and was once used in the treatment of
asthma
e. Quinine has been isolated from the Cinchona tree. Its major use is in the treatment of
migraine headaches - Answers -c. Morphine is extracted from the opium poppy and is
the gold standard for pain relief
Penicillin has the ability to combine with proteins to form antigens, and a small
percentage of the population receiving penicillin experience adverse effects. These
adverse effects are properly classified as:
, a. An extension of the therapeutic effect
b. An idiosyncratic reaction (based on genetic abnormality)
c. A drug allergy
d. Drug-drug interaction
e. None of the above - Answers -c. A drug allergy
Which one of the following statements is correct?
a. Streptomycin was introduced for the treatment of tuberculosis by Paul Ehrlich
b. In the 1950's a Swiss pharmaceutical firm isolated chloropromazine from the
rauwolifa plant
c. Penicillin was introduced into therapy by Waksman
d. Albert Hoffmann accidentally ingested a small amount of curare while synthesizing
this compound and experienced a hallucinogenic effect
e. Ether was first successfully used for anesthesia by Morton at the Massachusetts
General Hospital - Answers -e. Ether was first successfully used for anesthesia by
Morton at the Massachusetts General Hospital
The sound and long established way to prove or disprove the value of a new medication
or treatment is a controlled study. This includes:
a. A random selection of patients for the various test groups
b. One group of patients receives the new drug, and a similar group of patients receives
the control drug (gold-standard or placebo)
c. The patients do not know if they are receiving the new drug or the control drug
d. The people who administer the drugs and record the results do not know who is
receiving the new drug or the control drug
e. All of the above - Answers -e. All of the above
Which of the following statements is correct?
a. A placebo is defined as an inert substance masquerading as a drug
b. The likelihood of placebo effects is greater in normal volunteers than in sick anxious
patients under stress
c. Placebo effects are those reactions to drug administration which arise from the very
act of taking the drug but result in real pharmacological effects
d. Placebo responses are well understood and thus need not be controlled in a Phase II
study
e. Placebo therapy provides satisfactory relief in approximately 15% of patients with
cough, headache, anxiety, tension, the common cold, and postoperative wound pain -
Answers -a. A placebo is defined as an inert substance masquerading as a drug
The autonomic nervous system has as its major function:
a. Control of emotion
b. Control of memory and cognition
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