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MCB FINAL EXAM LON CAPA + DISCUSSION QUESTIONS AND ANSWERS
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MCB FINAL EXAM LON CAPA + DISCUSSION QUESTIONS AND ANSWERS
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MCB FINAL EXAM LON CAPA + DISCUSSIONQUESTIONS AND ANSWERS
The figure above is a cartoon of the plus end of an individual
microtubule. Based on our discussion in lecture, which of the following
statements is correct? - Precise Answer ✔✔The plus end is shrinking
True or False: The two ends of a microtubule that is growing in vitro
(with neither end capped) have different critical concentrations. - Precise
Answer ✔✔True
Which of the following is/are MAPs?
Protein(s) that bind the GTP cap and promote assembly of microtubules
Proteins that promote bending of proto-filaments and promote
disassembly of microtubules
Proteins that bind the sides of microtubules and connect to other proteins
such as intermediate filament
Protein(s) that bind the GTP cap and promote assembly of microtubules,
and proteins that bind the sides of microtubules and connect to other
proteins such as intermediate filaments
All of the above - Precise Answer ✔✔All of the above
True or False: As described in lecture, microtubule assembly is best
described as an equilibrium reaction rather than a steady state reaction. -
Precise Answer ✔✔False
, True or False: As discussed in lecture, there are no known motor
proteins that move along intermediate filaments. - Precise Answer
✔✔True
By measuring microtubule growth, you find that they grow at a rate of 3
μm/min (this number has been altered to make the following calculation
easier). At this growth rate, approximately how many alpha/beta tubulin
dimers (8 nm in length) are added to the ends of a microtubule each
second (don't forget there are 13 protofilaments/microtubule)? - Precise
Answer ✔✔3000 nm/60 sec = 50 nm/sec x dimer/8 nm = ~6 dimers/sec
to each of 13 protofilaments = 78 tubulin dimers added per second
Dynamic instability causes microtubules to grow and shrink rapidly.
Consider a microtubule that is in its shrinking phase. Why is it
shrinking, and what must happen at the end of the microtubule for it to
stop shrinking and start growing? - Precise Answer ✔✔A microtubule
that is shrinking has more GDP than GTP. To begin growing a "GTP"
cap must be added so that it grows again.
True or False: As discussed in lecture, microtubules that are anchored in
a centrosome are nucleated by and are extensions of the microtubules
that comprise the centrioles. - Precise Answer ✔✔False
True or False: As discussed in lecture, within a centrosome the two
centrioles are identical to each other. - Precise Answer ✔✔False, one is
a mother and one is a daughter
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