Anemia - ANSWER decrease in RBCs (quantity) or oxygen carrying capacity of
existing RBCs (quality)
reticulum stem cells
normoblasts
reticulocytes
erythrocyte - ANSWER what is the path of maturation of a blood cell (all
occurs in bone marrow except or last stage)
decreased RBC production
increased RBC destruction
blood loss - ANSWER 3 main causes of anemia
bone marrow - ANSWER what type of anemia is due to a production of RBC
issue
hemolytic anemias - ANSWER what type of anemias are caused by
destruction of RBCs
microcytic - ANSWER iron deficiency anemia is what type of anemia
macrocytic - ANSWER Folate deficiency anemia is what type of anemia
4.5 mil/mm^3
,men - ANSWER what is the normal RBC levels, it is higher normally in men or
women
<12 g/dL - ANSWER someone has anemia if their Hb drops below what
hematocrit - ANSWER the % of packed RBCs in a whole blood
40 - ANSWER what is a normal hematocrit level
RBCs
Hb
hematocrit - ANSWER 3 major measurements for anemia
pallor
blood in stool
jaundice
spooning fingernails - ANSWER signs of anemia
CVD - ANSWER what can anemia increase your risk of
pallor - ANSWER Extreme or unnatural paleness
>30%
11 g/dL - ANSWER what hct and Hb counts do you want if you are doing a
major surgery
<25% , 8 g/dL - ANSWER if Hct and Hb are below these levels the pt needs a
blood transfusion
anemia - ANSWER if someone has balding mucosa that means they usually
have
, beta chain 6th amino acid
glutamic acid > valine - ANSWER what mutation occurs in the hemoglobin of
a person with sickle cell diease
sickle cell trait - ANSWER disorder in which individuals show signs of mild
anemia only when they are seriously deprived of oxygen; occurs in
individuals who have one dominant allele for normal blood cells and one
recessive sickle-cell allele
ischemia
infarction
inflammation - ANSWER 3 I's of clinical greater of a sickle cell crisis
the shape of the sickle cell causes it to get stuck - ANSWER what is the
underlying pathophysiology of a sickle cell crisis
sickle cell trait - ANSWER sickle cell trait or disease is the heterozygous state?
hydroxyurea - ANSWER what drug is used to trade SCT and works by
stimulating feetal Hb & INCREASES FLEXIBILITY fo cells
L-glutamine - ANSWER what drug is used to trade SCT and works by
neutralizing oxidative stress (lowers conversion to sickle shape)
hydroxyurea & L-glutamine - ANSWER two drugs used to treat SCT
hypoxia (give O2)
severe infection
dehydration (drink water) - ANSWER 3 circumstances were SCT can
potentially be a problem for dentists
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