AOCNP Test Review Questions and Correct Verified Answers
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Course
AOCNP
Institution
AOCNP
Treatments that place individuals at increased risk for infection
Chemotherapy treatments including high-dose cyclophosphamide, doxorubicin,
docetaxel, or alemtuzumab.
Colony stimulating factors (CSF)
**GM-CSF : growth factor for hematopoietic stem cells and
granulocyte/monocytes
**M-CSF...
AOCNP Test Review Questions and
Correct Verified Answers
Treatments that place individuals at increased risk for infection
✓ Chemotherapy treatments including high-dose cyclophosphamide, doxorubicin,
docetaxel, or alemtuzumab.
Colony stimulating factors (CSF)
✓ **GM-CSF : growth factor for hematopoietic stem cells and
granulocyte/monocytes
✓ **M-CSF (macrophage): essential for macrophage production
✓ **G-CSF (granulocyte) :essential for neutrophils
✓ **Erythropoietin (EPO): growth factor for RBC
Filgrastim (Neupogen)
Pegfilgrastim (Neulasta)
Tbo-filgrastim (Granix)
✓ Common side effects: mild to moderate bone pain
✓ Used to patients at risk of experiencing treatment induced neutropenia
✓ Major benefit: reducing the possibility of myelosuppression and permitting the
continuation of therapeutic chemotherapy doses
Filgrastim (Neupogen)
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✓ Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after completion of
chemotherapy and continue through the post nadir period.
Pegfilgrastim (Neulasta)
✓ That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy. Administer as a
single 6 mg injection once per cycle. Do not administer in the period beginning
14 days before until 24 hours after administration of chemotherapy.
Antimicrobial prophylaxis for infection
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✓ Low risk: no prophylaxis Recommended unless the patient has prior herpes
simplex virus episode.
✓
✓ Intermediate risk:
✓ Bacterial: consider Fluoroquinolone
✓ Fungal: consider fluconazole during neutropenia and if mucositis is anticipated
✓ Viral: during neutropenia and at least 30 days after transplantation
✓
✓ High risk:
✓ Bacterial: consider fluoroquinolone
✓ Fungal: consider fluconazole or other anti-fungal agent
✓ Viral: during neutropenia and at least 30 days after transplantation
✓ Graft versus host disease: penicillin andtrimethroprim/sulfamethoxazole
(tmp/smx) Or equivalent for allogenic heamatopoetic Stem cell transplant
recipients
✓ Alemtuzumab: TMP/SMX
Complete diagnostic work up for neutropenic fever
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✓ Blood cultures: bacterial, viral, and fungal
✓ BUN, electrolytes, and creatinine
✓ Chest x-ray
✓ CBC and differential
✓ Liver function test
✓ Pulse oximetry
✓ Site-specific cytology and cultures
✓ Urinanalysis
ANC calculation
✓ WBC x [(% segs + % bands)/100]
aplastic anemia
✓ a normocytic-normochromic type of anemia characterized by the failure of bone
marrow to produce red blood cells
hemolytic anemia
✓ characterized by an inadequate number of circulating red blood cells due to the
premature destruction of red blood cells by the spleen
deficiency anemia
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