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PHAR 100 Final Exam Questions With Answers
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PHAR 100 Final Exam Questions With Answers
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PHAR 100 Final Exam Questions With AnswersPhase One Drug Trial - Small number of people
Absorption, distribution, elimination, and adverse effects are monitored
Phase Two Drug Trial - Small number of people
Determines if drug is effective in treatment
Phase Three Drug Trial - Large number of people
Safety of drug is carefully studied
Potency - Amount of drug that must be given to obtain a response
Efficacy - Maximum effect of the drug
Paul Ehrlich - Organoarsenic compounds
Salvarsan: syphilis treatment
Gerhard Domagk - Sulfonamides
Prontosil: streptococcus
Antimetabolites - Act against substances required for metabolism of an organism
Example: sulfanilamide
Sulfanilamide - Antimetabolite
Therapeutic Index - Lethal Dose (Toxicity) ÷ Effective Dose
Higher means safer
, Parenteral Routes - Intramuscular
Subcutaneous
Intravenous
Enteral Routes - Mouth
Rectal
Under Tongue
Drug Dependence - Physical dependence
Psychological dependence
Tolerance
Abuse Potential - Dependence liability
Availability of drug
Harmfulness
CNS Depressants - Alcohol
Barbiturates
Benzodiazepines
Sedative-Hypnotics - Barbiturates
Benzodiazepines
Benzodiazepines - Activate GABA
High therapeutic index
Relief from anxiety
Example: Diazepine, Flurazepam
Gamma-Amino-butyric Acid (GABA) - Major inhibitory neurotransmitter in CNS
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