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PHM 431 Exam 1 Questions and Answers
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PHM 431 Exam 1 Questions and Answers
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PHM 431 Exam 1 Questions andAnswers
Describe drug tolerance - Answer-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for
example)
What is a drug that could easily cross the blood brain barrier? - Answer-Hydrophobic
drug (molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? -
Answer-A non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug
is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape
of Drug A but is further right on the graph. What does this mean? - Answer-Drug A is a
full agonist; Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - Answer-Chemical antagonism
(drug interacts with another chemical to inactivate drug or make it inaccessible to site of
action)
Many factors affect risk for drug addiction. What factor would NOT increase risk that an
individual will become addicted to a drug? - Answer-High level of plasma protein binding
(Would increase are: high BBB permeability, release of DA in NAc, and rapid onset of
drug action)
Figure with drug naive curve on left and drug experienced curve further right shows
what pharmacodynamic principle? - Answer-Drug tolerance
Drug A is furthest left and middle height. Drug B is in the middle and has lowest height.
Drug C is furthest right and has highest height. What does this signify? - Answer-Drug C
is the lowest potency, highest efficacy agonist (X axis position determines potency, Y
axis determines efficacy/response size)
What term belongs with myelin sheath and Node of Ranvier? - Answer-Saltatory
conduction (APs jump node to node)
Activation of what type of ion channel is responsible for the rising phase of an AP? -
Answer-Sodium channel
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