NURS 3119 Introduction to Pharm Exam 1
Questions With Correct Answers
What is Pharmacokinetics? - answer✔The movement of medications in the body (what the
body does to the drug)
What are the 4 Phases of Pharmacokinetics? - answer✔1. Absorption
2. Distribution
3. Metabolism
4. Excretion
What is Pharmacodynamics? - answer✔The body's physiologic response to the drug (what the
drug does to the body)
What are Examples of Pharmacodynamics? - answer✔>Tolerance
>Toxicity
>Interactions
>Side affects/adverse effects
What is Absorption in Pharmacokinetics? - answer✔The movement of the drug from the site of
administration to bloodstream
Does the Amount of drug Absorbed determine the Strength of Response? - answer✔Yes
How does the Enteral Route of Administration Impact Absorption? - answer✔Less absorption
related to gastric pH, food
How does the Sublingual/Buccal/Suppository Route of Administration Impact Absorption? -
answer✔Quick absorb through vascular mucous membranes
How does the Inhalation Route of Administration Impact Absorption? - answer✔Quick absorb;
impacted by inspiratory effort and lung consolidation
How does the Topical/Intradermal Route of Administration Impact Absorption? -
answer✔Slower; consider placement
How does the IM Route of Administration Impact Absorption? - answer✔Quicker; impacted by
solubility of medication, blood flow to injection site
How does the IV Route of Administration Impact Absorption? - answer✔Immediate and full
absorption
What is Distribution in Pharmacokinetics? - answer✔Transportation of a drug from the
bloodstream to the site of action
What is Distribution in Pharmacokinetics Impacted by? - answer✔>Perfusion
>Ability of medication to travel between capillary cells and membranes
>Competition for binding sites
>Some medications are "protein bound" and need proteins to move
What is a Common Protein for Distribution? - answer✔Albumin; medications that cannot find
Albumin to bind to becomes free drug in the blood stream
What is Competition for Binding Sites? - answer✔Higher risk when using multiple meds, leads
to unbound (free) in the bloodstream
What is Drug Binding? - answer✔Medications bind to receptor sites and either increase or
decrease the activity of that site
What is an Agonist Binding Site? Example? - answer✔Binds to a site and mimics the activity of
that receptor.
>Opioid Agonist (Fentanyl) binds to Mu receptor site to block pain reception - also blocks
respiratory drive among other things
What is an Antagonist Binding Site? Example? - answer✔Binds to the site and blocks the activity
of that receptor
>Naloxone (Narcan) binds to the Mu receptor to push off the opioids to reverse drug effects
(increase respirations)
What is a Partial Agonist Binding Site? Example? - answer✔Binds to more than one receptor
site and can act as either, depending on the receptor site
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