what are the indications of lamotrigine? - CORRECT
ANSWER-bipolar, depression
can help with chronic pain
what is the starting dose of lamotrigine? - CORRECT
ANSWER-25 mg/day for 1 and 2 weeks, then 50 mg/day for 3
and 4 weeks, then 100 mg/day for 5 week, then 200 mg/day for
6 week, and beyond
what lab test to complete with lamotrigine? - CORRECT
ANSWER-liver
what is most concerning side effect of lamotrigine? - CORRECT
ANSWER-steven johnson syndrome
,2|Page
what are the most common side effects of lamotrigine? -
CORRECT ANSWER-GI upset, sedation
how do lamotrigine and valproic acid interact? - CORRECT
ANSWER-valproic acid increases lamotrigine levels
lamotrigine decreases valproic acid levels
what antipsychotics might help with mania? - CORRECT
ANSWER-"AZROQ"
what antipsychotics are best for bipolar maitenance? -
CORRECT ANSWER-ziprasidone
olanzapine
quetiapine
,3|Page
what antipsychotic might best help depressive symptoms of
bipolar? - CORRECT ANSWER-quetiapine XR
what drugs have the highest risk of steven johnson syndrome? -
CORRECT ANSWER-valproic acid
lamotrigine
carbamazepine
oxcarbazepine
what 4 domains should be evaluated when deciding how to treat
bipolar disorder? - CORRECT ANSWER-- acute mania
- acute depression
- prophylaxis against mania
- prophylaxis against depression
what 3 medications are best for acute mania? - CORRECT
ANSWER-valproic acid (1000mg/day acute mania; can dose at
250mg TID)
lithium (300mg TID)
olanzapine (10mg/day)
what medication isnt very good for acute mania? - CORRECT
ANSWER-lamotrigine (slow titration)
, 4|Page
what is the loading dose regimen for valproic acid? - CORRECT
ANSWER-30mg/kg/day x 3 days; then 20mg/kg/day
what medication is best for mania prophylaxis? and what other
medications help? - CORRECT ANSWER-**lithium
atypical antipsychotics
valproic acid
carbamazapine
what medications help treat acute bipolar depression? -
CORRECT ANSWER-**atypical antipsychotics
-- quetiapine, olanzapine, lurasidone
lithium
lamotrigine
what medications help with bipolar depression prophylaxis? -
CORRECT ANSWER-lamotrigine
atypical antipsychotics
lithium
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