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UNE Biochemistry Final Exam Questions and Answers
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UNE Biochemistry Final Exam Questions and Answers
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UNE Biochemistry Final Exam Questionsand Answers
What are the direct products of Beta Oxidation? - Answers -NADH
FADH2
Acetyl CoA
What does Acetyl CoA get used for - Answers -ketogenesis
allosterically activates Pyruvate Carboxylase
An 11yo girl is brought into the emergency department by her father. He reports that
she has recently been very thirsty and needing to make frequent trips to the bathroom.
At her soccer game today, she complained of lightheadedness and symptoms did not
resolve even after drinking a power beverage. A rapid dipstick test revealed glucose in
her urine and further diagnostics indicate with a diagnosis of Type 1 Diabetes.
Evaluation of the liver would indicate an increased amount of which of the following
processes? - Answers -Ketogenesis
What is the role of adipose in metabolism? - Answers -storage of triacyglycerols
appetite regulation, coagulation, immunity, reproduction
A 5yo female is brought into the ED by her mother. She is a type 1 diabetic and has not
taken her insulin while away at a day camp. The child is unresponsive. Which of the
following enzymes is phosphorylated and active under these conditions? - Answers -
hormone sensitive lipase
An individual goes to bed around 8 pm and doesn't wake up until 9 am the next
morning. During this time, which of the following is the primary oxidizable substrate in
the skeletal muscle? - Answers -free fatty acids
An individual is on a hunger strike and has not eaten in 13 days. Which of the following
best describes their metabolic state? - Answers -The brain will be preferentially
oxidizing ketones
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane.
The transport of fatty acids via carnitine palmitoyl transferase I (CPTI) can be directly
inhibited by which of the following compounds? - Answers -Malonyl CoA
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon will activate
which of the following enzymes? - Answers -Hormone Sensitive Lipase
, A well, 2-year-old girl presents to the clinic with symptoms of a viral illness. Her parents
report she has had bouts of vomiting and diarrhea over the last 24 hours. This morning
they could barely wake her from her crib and she was very weak. Laboratory tests show
low blood glucose (hypoglycemia) and elevated liver enzymes. There are no ketones
present in her urine. The child is hospitalized and glucose is administered by I.V.
Additional laboratory analysis showed elevated medium-chain fatty acyl carnitines in
blood and 6-8 carbon dicarboxylic acids in the urine. Which of the following
abnormalities is the most likely diagnosis for this child? - Answers -Defect of medium-
chain acyl-dehydrogenase
A 22-year-old woman engaging in a political protest goes on a hunger strike on a
prominent corner in a city park. She refuses all offers of food except for water through
the first 2 weeks. Under these conditions there is a decreased reliance on which of the
following pathways for fuel? - Answers -Gluconeogenesis
ATP can be generated by many metabolic pathways in the body. Which of the following
processes generates the most ATP? - Answers -Fatty acid beta oxidation
In liver, which of the following key inhibitory events ensures that newly synthesized
palmitoyl-CoA is not immediately oxidized? - Answers -Inhibition of carnitine-palmitoyl
transferase-I (CPT-I) by malonyl-CoA.
An increase in the ratio of insulin to glucagon will increase which of the following
enzymes? - Answers -hormone sensitive lipase decreases
acetyl CoA carboxylase increases
Phosphofructokinase 2 increases
glycogen synthase increases
NADPH is essential for fatty acid synthesis and can be generated by which two
enzymes? (+ indicates NADPH can be produced by the enzyme; - indicates the enzyme
does not produce NAPDH) For G6P Dehydrogenase, Malic Enzyme, and Pyruvate
Dehydrogenase Complex - Answers -+, +, -
A defect in the thioesterase subunit of fatty acid synthase would impair which of the
following activities of the enzyme complex? - Answers -Liberation of newly assembled
palmitate from the enzyme
Malate can be converted to pyruvate in the cytosol. Which of the following compounds
is directly generated in this conversion and is essential for fatty acid synthesis? -
Answers -NADPH
Which of the following enzymes is correctly paired with its allosteric inhibitor? - Answers
-Acetyl-CoA carboxylase: palmitoyl-CoA
An increase in the ratio of insulin to glucagon leads to which of the following metabolic
shifts? - Answers -Acetyl-CoA carboxylase will become dephosphorylated and active
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