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Week 9 UNE Biochem Exam Questions and Answers
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Week 9 UNE Biochem Exam Questions and Answers
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Week 9 UNE Biochem Exam Questionsand Answers
Insulin: The description here is of type 1 diabetes which is consistent with a loss of
insulin production. Therefore, fasted state metabolic pathways would be highly active
contributing to hyperglycemia and ketogenesis. - Answers -1 out of 1 points
An 10-year-old boy is brought to the emergency department by his father. He reports his
son has recently been very thirsty and needing to make frequent trips to the bathroom.
Physical examination revealed a thin boy, in the 30th percentile for height and weight. A
rapid dipstick test revealed glucose in his urine. Evaluation of this boy's blood would
reveal decreased levels of which of the following compounds or hormones?
D-3-hydroxybutyrate or β-hydroxybutyrate : Ketogenesis is the process by which excess
acetyl-CoA from β-oxidation is converted to the ketone bodies: D-3-hydroxybutyrate (β-
hydroxybutyrate) and acetoacetate. - Answers -The process of ketogenesis refers to the
conversion of acetyl-CoA to which of the following compounds?
D-3-hydroxybutyrate and acetoacetate: Ketogenesis is the process by which excess
acetyl-CoA from β-oxidation is converted to the ketone bodies: β-hydroxybutyrate and
acetoacetate. - Answers -Ketonuria, hyperglycemia and severe acidosis are prime
diagnostic indicators of the presentation of type 1 diabetic ketoacidosis. Which of the
following compounds are "ketone bodies" that would be elevated in serum and urine of
a patient in this condition?
hormone sensitive lipase: Glucagon will increase levels of lipolysis through the
phosphorylation and activation of hormone sensitive lipase. - Answers -Under fasting
conditions (ratio of insulin to glucagon <1), elevated glucagon will activate which of the
following enzymes?
Fatty acid β-oxidation: 7 NADH, 7 FADH2 and 8 acetyl-CoA are all produced by β-
oxidation of a C16 fatty acid. This will generate 108 mol ATP/ mol palmitate. - Answers -
ATP can be generated by many metabolic pathways in the body. Which of the following
processes generates the most ATP?
Malonyl CoA: Malonyl-CoA produced in the cytosol as part of fatty acid synthesis will
inhibit the transport of fatty acids across the mitochondrial membrane such that fatty
acid synthesis is not occurring at the same time as β-oxidation. - Answers -In the fasted
state, fatty acyl-CoAs are transported across the mitochondrial membrane. The
transport of fatty acids via carnitine palmitoyl transferase I (CPTI) can be directly
inhibited by which of the following compounds?
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