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Barry BMS Immunology Test 1 with correct Answers
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Barry BMS Immunology Test 1
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Barry BMS Immunology Test 1Antigen Shape to Antibody Shape - Answers -Simple = Pocket
Large = Groove
Complex = Extended Surface
Type of chemical bond used with antibodies - Answers -1)Electrostatic
2) Hydrogen bonds
3) Van der Waals forces
4) Hydrophobic interactions
Cross reactivity - Answers -The biding site can accept a shape close enough in shape
and get reaction or a stable structure
Ex. Penicillin and other B-lactam
Diagnostic tests for antibody/antigen - Answers -ELISA
Lateral Flow test (pregnancy hCG)
Immunofluorescence (Direct or indirect) (color tag)
Flow Cytometry
MHC - Answers -In humans HLA
Extremely polymorphic
codominantly expressed (both parents expressed)
Class 3 rare
MHC I - Answers -CD8, Cytosol, Closed (fixed size antigen)
Made in ER
Heterodimer
α MHC chain and β2 microglobulin
MHC II - Answers -CD4, Extracelluar, Opened
, Heterodimer
α and β MHC chains
Ig vs, TCR - Answers -Both: Before antigen
Many V domains
recombination
junctional variabilty
Many chain combos (light/heavy & a/b)
After Antigin:
TCR DONT hypermutation or Class Switch
dendritic cells - Answers -APC (most efficiant)
2 types Conventional and Plasmacytoid
Steps for antigen presentation - Answers -Processing: when antigens recognize self
MHC molecules for presentation to T-cells.
Presenting by APCs
Target cells
Lymphocytes activation - Answers -- Antigen
- Binding (TCR, BCR, Coreceptors)
- Signal Transduction (ITAM, Tyrosine kinasas)
- Amplication
- Trans. Factors
- Cell Response (proflieration, Ig, cytokine)
What ITAM stands for & does? - Answers -Immuno-receptor tyrosine-based activation
motif
When phosphorylated ITAMS pass the activation signal from cell surface to the
cytoplasm
B cell co-receptor - Answers -CD21/CD19/CD81
T cell co-receptors - Answers -CD4 and CD8
CD3 and Zeta CD3 (have ITAMs)
Lymphocyte activation Response - Answers -Up-regulation of transcription
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