NSG 552 Psychopharmacology Exam 1 -
Modules 1-3 Questions With Answers 100%
Correct
EPS Involuntary movements that occur as a side effect to certina medications. AKA drug
induced movement disorder. May include tardive dyskinesia, dystonic reactions, parkinsons-like
symptoms, akathesia, NMD,...
Upregulation Refers to the activiation of the nervous system. Is the process by which a
cell increases its response to a subtance or signal from outside the cell to carry out a specific
response
, NSG 552 Psychopharmacology Exam 1 -
Modules 1-3 Questions With Answers 100%
Correct
downregulation Refers to state of calm/relation within nervous system. Characterized by a
decreased response by a cell to a molecule or neurotransmitter.
Receptor Profiles FGA - Primarily D2 antagonism. Also antagonize M2, H1, and a1
Binding When a neurotransmitter binds to a receptor on a receiving cell, it causes ion
channels to open or close.
Affinity The property of a drug that describes its ability to bind to a receptor
Constant
Unique for each drug-receptor pair as it is dependent on each of their structures
CYP450 - membrane-bound hemoproteins that play a pivotal role in the detoxification of
xenobiotics, cellular metabolism, and homeostatis
, NSG 552 Psychopharmacology Exam 1 -
Modules 1-3 Questions With Answers 100%
Correct
-Inhibitition or induction of CYP enzymes is a major mechanism underlying drug-drug
interactions
- A CYP450 inhibitor prevents or reduces work by CYP450 enzymes = decreased drug
metabolism and increased risk for toxicity
- A CYP450 inducer increases rate of hepatic metabolism = decreased serum concentation of
other drugs metabolized by the same hepatic isoenzyme
Grapefruit juice is an inhibtior, which can increase serum levels of certain drugs
Dopamine Pathways - mesolimbic (positive sx)
- mesocortical (negative sx)
- nigrostriatal (EPS)
- tuberoinfundibular (prolactin)
Metabolic Syndrome cluster of conditions that incerase risk for T2DM and cardiovascular
disease (obesity, HTN, high triglycerides, low HDL, insulin resistance)
-increased risk for metabolic syndrome found with some antipsychotic medications, primarily
SGA
, NSG 552 Psychopharmacology Exam 1 -
Modules 1-3 Questions With Answers 100%
Correct
High Potency vs Low Potency High potency: higher risk for EPS/hyperprolactinemia.
Effective at lower doses. Haldol, risperdal, prolixin, olanzapine
Low potency: more sedating with more anticholinergic symptoms. Thorazine, seroquel, clozaril,
geodon
Neuroleptic malignant syndrome (NMS) - Life threatening
- occur with use of dopamine receptor antagonists or when dopaminergic medidcation are
suddenly withdrawn
- sx usually begin within 2 wks of starting a new med or changing dose.
- Characterized by fever, AMS, muscle rigidity, autonomic dysfuncton
- Dantrolene sodium is FDA approved to treat. Muscle relaxant that reduces
hyperthermia/muscle stiffness
QTC interval -measurement of the left ventricle's repolarization efficiency on ECG.
- usually 350-450 (men), 360-460 (women)
-associated with life-threatening cardiac arrhythmias
-antipsychotic and antidepressant drugs can prolong QT intervals, some more than others
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller UpperClass. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $16.99. You're not tied to anything after your purchase.
