SUBSTANCE ABUSE
By MELAKU TESFAYE
Outline of the presentation
• Introduction
• Definition of terms
• Predisposing factors
• Theories of addiction
• Reward pathway and neurocircuitary of addiction
Molecular biology in Addiction
Liking and wanting
Neurobiology of relapse...
, Outline of the presentation
• Introduction
• Definition of terms
• Predisposing factors
• Theories of addiction
• Reward pathway and neurocircuitary of addiction
Molecular biology in Addiction
Liking and wanting
Neurobiology of relapse
• Classification of substance abuse
, Introduction
• Substance abuse is a widespread problem all over the
world.
• Globally, it is estimated that in 2010 between 153
million-300 million people aged 15-64 (3.4-6.6%
world’s population) had used an illicit substance at
least once in the previous year.
• approximately 1/100 deaths
• The economic cost was estimated at $180.9 billion
• 8.9% of the total burden of disease comes from the use
of psychoactive substances (tobacco -4.1%, alcohol 4%,
and illicit drugs 0.8% of the burden of disease)
, World drug report of 2012
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