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HESI Pharmacology Practice Questions and Answers UPDTAED 2025
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A client with mild parkinsonism is started on oral amantadine (Symmetrel). What statement accurately describes the action of this medication? -Correct Answer Dopamine in central nervous system is increased A 52-year-old client is admitted to the hospital for possible duodenal ulcers. The healthc...

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  • November 29, 2024
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  • 2024/2025
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  • hesi pharmacology practice questions and answers
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HESI Pharmacology Practice Questions Exam



HESI Pharmacology Practice Questions
and Answers UPDTAED 2025
A client with mild parkinsonism is started on oral amantadine (Symmetrel). What
statement accurately describes the action of this medication? -Correct Answer
✔Dopamine in central nervous system is increased

A 52-year-old client is admitted to the hospital for possible duodenal ulcers. The
healthcare provider prescribes ranitidine hydrochloride (Zantac) 150 mg BID PO. Which
data would indicate that this medication is effective? -Correct Answer ✔Within 4 hours
after meals, the client denies having pain.

A 78-year-old client with congestive heart failure receives the cardiac glycoside digoxin
(Lanoxin) 0.25 mg PO daily. Which observation by the nurse indicates that the
medication has been effective? -Correct Answer ✔Clear breath sounds anteriorly and
posteriorly

Minocycline (Minocin) 50 mg every 8 hours is prescribed for an adolescent girl
diagnosed with acne. The nurse discusses self-care with the client while she is taking
the medication. Which teaching points should be included in the discussion? (Select all
that apply.) -Correct Answer ✔Report vaginal itching or discharge.
Protect skin from natural and artificial ultraviolet light.
Avoid driving until response to medication is known.
Use a nonhormonal method of contraception if sexually active.

The nurse is assessing a stuporous client in the emergency department who is
suspected of overdosing with opioids. Which agent should the nurse prepare to
administer if the client becomes comatose? -Correct Answer ✔Naloxone hydrochloride
(Narcan)

The healthcare provider prescribes captopril (Capoten) 37.5 mg. The medication is
available in 25 mg tablets. What should the nurse administer? -Correct Answer ✔1½
tablets

A client who is HIV positive is receiving epoetin (Epogen) for management of anemia
secondary to zidovudine (AZT) therapy. Which laboratory finding is most important for
the nurse to report to the healthcare provider? -Correct Answer ✔Hematocrit (HCT) of
58%

A 75-year-old male client taking hydrochlorothiazide (HCTZ) is admitted to the hospital
having "palpitations" and "skipped heart beats." What is the most likely cause of these
symptoms given the client's medication history? -Correct Answer ✔Hypokalemia



HESI Pharmacology Practice Questions Exam

,HESI Pharmacology Practice Questions Exam


Which parameter is most important for the nurse to check prior to administering a
subcutaneous injection of heparin? -Correct Answer ✔Activated partial thromboplastin
time, commonly referred to as aPTT

A client is prescribed a cholinesterase inhibitor, and a family member asks the nurse
how this medication works. Which pharmacophysiologic explanation should the nurse
use to describe this class of drug? -Correct Answer ✔Improves nerve impulse
transmission

In developing a nursing care plan for a 9-month-old infant with cystic fibrosis, the nurse
writes a nursing diagnosis of Alteration in nutrition: less than body requirements, related
to inadequate digestion of nutrients. Which intervention would best meet this child's
needs? -Correct Answer ✔Give pancrelipase (Cotazym-S) capsule mixed with
applesauce before each meal.

When providing client teaching about the administration of methylphenidate (Ritalin) to
the mother of a child diagnosed with attention-deficit/hyperactive disorder (ADHD), what
instruction should the nurse include in the teaching plan? -Correct Answer ✔Offer the
child the medication before eating breakfast and after eating lunch.

Alteration of which laboratory finding represents achievement of a therapeutic goal for
heparin administration? -Correct Answer ✔Partial thromboplastin time

The charge nurse is reviewing the admission history and physical data for four clients
newly admitted to the unit. Which client is at greatest risk for adverse reactions to
medications? -Correct Answer ✔A 75-year-old woman with liver disease

The healthcare provider prescribes ipratropium (Atrovent) for a client. An allergic
reaction to what other medication would cause the nurse to question the prescription for
Atrovent? -Correct Answer ✔Atropine sulfate (Atropine)

68-year-old client has been diagnosed with open-angle glaucoma. The healthcare
provider prescribes pilocarpine (Isopto Carpine) eye drops. What action of this drug
makes it a useful treatment for the client's condition? -Correct Answer ✔The outflow of
aqueous humor in the eyes is increased.

The nurse is preparing to apply a surface anesthetic agent for a client. Which action
should the nurse implement to reduce the risk of systemic absorption? -Correct Answer
✔Avoid abraded skin areas when applying the anesthetic

The healthcare provider prescribes the anticonvulsant carbamazepine (Tegretol) for a
client with a seizure disorder. The nurse should instruct the client to notify the
healthcare provider if which condition occurs? -Correct Answer ✔Experiences a sore
throat



HESI Pharmacology Practice Questions Exam

, HESI Pharmacology Practice Questions Exam


chemotherapeutic regimen with doxorubicin HCl (Adriamycin) is being planned for a
client recently diagnosed with cancer. What diagnostic test results should the nurse
review prior to initiating this treatment? -Correct Answer ✔Electrocardiogram (ECG)

A client who is HIV positive is receiving combination therapy with the antiviral
medication zidovudine (Retrovir). What instruction should the nurse include in this
client's teaching plan? -Correct Answer ✔Return to the clinic every 2 weeks for blood
counts

A 67-year-old client is discharged from the hospital with a prescription for digoxin
(Lanoxin) 0.25 mg daily. Which instruction should the nurse include in this client's
discharge teaching plan? -Correct Answer ✔Take and record radial pulse rate daily.

Benztropine mesylate (Cogentin) and levodopa (Dopar) are prescribed for a client with
Parkinson's disease. After a few days of therapy, the client complains of a "dry mouth"
and "dizziness." What response by the nurse would be most appropriate? -Correct
Answer ✔"Chew gum to relieve the dry mouth and move slowly when assuming a
standing position to reduce the dizziness

Vancomycin (Vancocin) is prescribed for a client who has a history of endocarditis and
is to undergo minor dental surgery. The nurse knows that this drug -Correct Answer
✔may be administered PO.

Which assessment finding could indicate to the nurse that a client is experiencing an
adverse effect of the gastrointestinal stimulant metoclopramide HCl (Reglan)? -Correct
Answer ✔Demonstrates Parkinson-like symptoms, such as cogwheel rigidity

Methylphenidate HCl (Concerta) 18 mg PO is prescribed for daily administration to a 10-
year-old child with attention-deficit/hyperactive disorder (ADHD). In preparing a teaching
plan for the parents of this newly diagnosed ADHD child, which instruction is most
important for the nurse to provide the parents? -Correct Answer ✔Administer the
medication in the morning before the child goes to school.

The nurse is preparing to administer amphotericin B (Fungizone) IV to a client. What
laboratory data are most important for the nurse to assess before initiating an IV
infusion of this medication? -Correct Answer ✔Serum potassium

A client with angina pectoris is instructed to take sublingual nitroglycerin tablets PRN for
chest pain. Which instruction should the nurse include in the client's teaching plan? -
Correct Answer ✔Take 1 tablet at the onset of angina and stop activity.

Rationale:
Nitroglycerin tablets should be taken at the onset of angina, and the client should stop
activity and rest (B). One tablet can by taken every 5 minutes, up to three doses (A).



HESI Pharmacology Practice Questions Exam

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