ALL RIGHTS RESERVED.
What is the MOA of Spironolactone (Aldactone)? - answer✔Aldosterone antagonist, acts in late
distal convoluted tubule and collecting duct (minimal diuresis effect), Potassium retention and
Sodium excretion
What are the major adverse effects of Spironolactone (Aldactone)? - answer✔Hyperkalemia,
antiadronergic effects
How does Spironolactone (Aldactone) affect Potassium levels? - answer✔Potassium sparing
What class does Mannitol belong to? - answer✔Osmotic Diuretic
What does Mannitol do to the body? - answer✔Prevents renal failure, reduces ICP
What are some examples of Angiotensin-Converting Enzyme (ACE) Inhibitors? -
answer✔Captopril, Lisinopril
What are the major adverse effects of ACE Inhibitors? - answer✔Angioedema, cough,
electrolyte/fluid imbalance (ACE)
What class does Losartan belong to? - answer✔Angiotensin II Receptor Blockers (ARBs)
What are the major adverse effects of Losartan? - answer✔Angioedema, cough, electrolyte/
fluid imbalance (less cough and chance for Hyperkalemia than ACE Inhibitors)
What class does Aliskiren belong to? - answer✔Direct Renin Inhibitors (DRIs)
What is a contraindication of Aliskiren? - answer✔Pregnancy
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