Describe the different types of junctions and what their functions are - -Occluding
Junction: Tight Junction-Prevents molecules from passing between cells; prevents
membrane proteins from moving to membrane at other end of cell
-Anchoring Junction: Desmosomes (IF- bind cell to cell), hemidesmosomes (IF-
binds to matrix), focal adhesion points, adherence points
-Communicating Junction=Gap junction: Allows molecules to pass, must be less
than 5000 Daltons
What are occluding junctions? - Tight Junction-Prevents molecules from passing
between cells; prevents membrane proteins from moving to membrane at other
end of cell
What are anchoring junctions? - Desmosomes, hemidesmosomes, focal adhesion
points, adherence points
What are communicating junctions? - Gap junction: Allows molecules to pass,
must be less than 5000 Daltons
, Describe the role of tight junctions in intestinal epithelial cells. - Keeps the
Na/glucose pump on the top (lumen/apical) and the passive glucose transport
must stay on the basal side of the cell
-Prevents passing of small molecules and movement of membrane proteins
What proteins are present in tight junctions? - Claudins and occludins
What is the difference between adherence junctions and desmosomes? -
Adherenance junction: adhesion belt: anchor actin and adjacent cells
Desmosomes anchor intermediate filaments and adjacent cells
What is the difference between hemidesmosomes and focal adhesions? -
Hemidesmosomes anchor cells to the extracellular matrix
Focal adhesions anchor actin to extracellular matrix
What is the difference between hemidesmosomes and desmosomes? -
Desmosomes anchor intermediate filaments and adjacent cells
Hemidesmosomes anchor cells to the extracellular matrix
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