Exam (elaborations)
Bio. 344 (cellular and molecular) Final Questions answers latest update
- Course
- Bio 344
- Institution
- University Of Texas - Austin
Bio. 344 (cellular and molecular) Final Questions answers latest update
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Bio. 344 (cellular and molecular) FinalNF-kB can activate genes during the immune response by a protein kinase that: -
Phosphorylates the inhibitory factor 1kB, causing it to be degraded and release
NF-kB
Ras is a membrane-bound ________ when activated. - Monomeric G protein that
binds GTP
TGF-B receptors acct by phosphorylating the protein ________. - Smad
In the Jak-Stat signaling pathways, activation/signaling steps involve: - 1) Receptor
dimerization
2) JAKS phosphorylate tyrosines on receptors to create docking sites for STATS
3) JAKS phosphorlyate STATS
4) Phosphorylated STATS form heterodimers that translocate to the nucleus
Notch/Delta signaling - Once proteolytically cleaved, a piece of the notch
molecule enters the nucleus and activates transcription of target genes.
What is involved in the pathway that regulates and inactivates BAD? - 1) Receptor
tyrosine Kinase
2) PI-3 kinase
, 3) PDK1
4) AKT (Protein Kinase B)
Activation of AKT requires: - Activation of PI3-kinase
In the presence of a Wnt signal; - B-catenin is translocated to the nucleus, where
it induces transcription of Wnt target genes.
Hedgehog signal - 1) Absence = cleaved portion of Ci protein; acts as a
transcription repressor
2) Presence = cleaved portion of Ci protein; acts as a transcription activator
A mutation in APC is associated with colon cancer, what signal pathway is affected
by this mutation? - Wnt signaling pathway
Nuclear Receptors - Have ligand-binding and DNA-binding domains, and can
directly bind to DNA.
What will activate Ras? - Ras GEF (SoS)
A mannose-6-phosphate (MP6) is added to proteins destined for _______ in the
______. - Lysosomes; Golgi
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