chain of events including second messengers, enzymes and activated proteins
that follow ligand binding to a receptor
Why do cells have signaling pathways?
Cells have signaling pathways to survive, to divide, to differentiate, and to die.
What is the difference between a cell surface and an intracellular receptor? How
do the signals for these two types of receptors differ?
The difference between a cell surface and an intracellular receptor is that a cell
surface receptor is involved in extracellular signaling and is in the cell membrane
and an intracellular receptor is inside of the cell. Extracellular signaling molecules
are small, hydrophobic molecules, where as intracellular signaling molecules are
small and hydrophilic.
What are the 4 forms of intercellular signaling?
The 4 forms of intercellular signaling are contact-dependent, paracrine, synaptic,
and endocrine signaling.
What is autocrine signaling? Why do cells use it when deciding to differentiate(I.e.
change cell type)?
Autocrine signaling is a subunit of paracrine signaling. It involves a group of cells
that release a signaling molecule and put there receptor out at the same time to
determine a community decision. Cells use it when deciding to differentiate
because depending on the signaling molecule, the ones who have that receptor
can all differentiate at the same time.
What is a hormone?
, A hormone is a chemical messenger.
What determines if a cell survives, divides, differentiates, or dies?
A signaling molecule such as survival factors, growth factors(mitogens),
differential factors, and no signal molecules for when a cell dies.
Does acetylcholine always cause the same changes in different cells? Describe
some of the effect acetylcholine can cause in different cells.
Acetylcholine does not always cause the same changes in different cells. It can
cause saliva to be released from salivary cells, skeletal muscle contractions, and
relax the cardiac muscle cells.
What is nitric oxide? What role does it play in signaling pathways? What is it
made from?
Nitric oxide is a small, polar molecule that caused the vasodilation of a blood
vessel. Its role is to be an intracellular signaling molecule for a receptor in the
smooth muscle cell. It is made from arginine.
Describe the signaling process involving nitric oxide from a nerve cell to
vasodilation.
In the endothelial cells of the blood vessels, once Ach is released from the axon
terminal into the neuromuscular junction and is detected, arginine will make NO.
NO will then diffuse to the smooth muscle cells, where it will bind to aa receptor
in the cytosol which causes relaxation of the smooth muscle cell. Effectively
vasodilating the blood vessel.
What are nuclear receptors?
Nuclear receptors are ligand-regulated transcription factors that are activated by
steroid hormones.
What types of ligands do they bind?
Some ligands that they bind are estradiol, cortisol, estriol, testosterone.
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