100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Exam 3: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana $10.99
Add to cart
Quickly navigate to
Preview
  2.  
  3. Southeastern Louisiana University
  4.  
  5. NURS617/ NURS 617 (NURS617)

Exam (elaborations)

Exam 3: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana
 4 views  0 purchase

Exam 3: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana Q: Causes of Failure of Antimicrobial Therapy Answer: 1. Inadequate efficacy against the offending organisms 2. Inadequate bioavailab...

[Show more]

Preview 4 out of 41  pages

Document information

  • December 5, 2024
  • 41
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • southeastern louisiana pharmacotherapeutics exam
  • southeastern louisiana pharmacotherapeutics exam 1
  • southeastern louisiana pharmacotherapeutics exam 2
  • southeastern louisiana pharmacotherapeutics exam

Written for

All documents for this subject (8)

Seller

avatar-seller
nurse_steph

Reviews received

Content preview

Examl3:lNURS617/lNURSl617l(Latestl
Update)lPharmacotherapeuticslGuide|lQsl&l
As|lGradelA|l100%lCorrectl(Verifiedl
Answers)-lSoutheasternlLouisiana

Q:lCausesloflFailureloflAntimicrobiallTherapyl
Answer:
1.lInadequatelefficacylagainstltheloffendinglorganisms
2.lInadequatelbioavailabilityloflthelselectedlagent
3.lInadequatelhostldefenselmechanisms
4.lInadequateldurationlofldrugltherapy
5.lSuperinfectionlorlbacteriallresistance



Q:lCausesloflFailureloflAntimicrobiallTherapy
1.lInadequatelefficacylagainstltheloffendinglorganismsl

Answer:
-lIncorrectlidentificationlofltheloffendinglorganism
-lUseloflaldrugltolwhichlorganismslhavelpreviouslylbecomelresistant
-lUseloflalmicrobiostaticlagentlwhenlalmicrobicidallagentlislnecessary



Q:lCausesloflFailureloflAntimicrobiallTherapy
2.lInadequatelbioavailabilityloflthelselectedlagentl

Answer:
-lUseloflanlincorrectldose
-lUseloflanlincorrectlroutelofladministration
-lUseloflanlincorrectldosinglinterval
-
lUseloflanlincorrectlantimicrobialltherapeuticlplan,lonelthatldoeslnotltakelintolconsiderationlthel
pharmacokineticlvariableslthatlexistlinltheltreatedlpatient

,Q:lCausesloflFailureloflAntimicrobiallTherapy
3.lInadequatelhostldefenselmechanismsl

Answer:
-
lFailingltolrecognizelthatlthelpatientlhaslinsufficientlimmunelresponseslneededltolassistlinlantim
icrobiallefficacy,lsuchlaslthoselwithlAIDS,lmalnutrition,limmunosuppression,lcancer,
patientslonlglucocorticoids,lpatientslwithllargelabscesses,lpatientslwithloverwhelminglsepsis,lan
dlpatientslharboringlnecroticltissues.



Q:lCausesloflFailureloflAntimicrobiallTherapy
4.lInadequateldurationlofldrugltherapyl

Answer:
Changingldrugslwithoutlevidencelofltreatmentlfailure
-
lTreatinglwithlcostlyldrugsl(thatlthelpatientlcannotlaffordltolbuy)lwhenllesslexpensiveldrugslwo
uldlhavelbeenlappropriate
-lTreatinglwithlhighlyltoxicldrugslwhenllesslharmfulldrugslwouldlhavelbeenlappropriate
-lFailureltolallowlforlvarianceslinlpatientlcompliancelforlalvarietyloflreasons



Q:lCausesloflFailureloflAntimicrobiallTherapy
5.lSuperinfectionlorlbacteriallresistancel

Answer:
Useloflbroad-spectrumlantibioticslwhenlmoreltargeted,lnarrow-
spectrumlagentslarelmorelappropriate
-lOtherlinappropriatelusesloflantimicrobiallagents



Q:lGenerallConsiderationslforlthelUseloflAntibioticsl
Answer:
ClassesloflAntibioticlDrugsl-lbasedlonlmechanismsloflactionloflthelantibiotics
1.lBlockadeloflpeptidoglycanlsynthesislislthelmajorlcomponentloflalbacteriallcelllwall.lBacterial
lcelllwallldestructionlallowslwaterltolenterlthelintracellularlmilieuloflthelbacteria,lcausingltheml
tolswell,llysel(explode)landldie.lInhibitionloflcelllwalllsynthesislislbacteriocidal.

,2.lDisruptionloflbacteriallcelllplasmalmembraneslbylbindingltollipoproteinslinlthelmembrane.lT
hislmechanismlonlyloccurslonlthelouterlmembraneloflsomelgram-negativelbacterial
organismslandlislusuallylbactericidal.
3.lBindingltolbacteriallribosomeslandlblockinglsomelbacteriallproteinlsynthesis.lDependinglonlt
helspecificlproteinlsyntheticlmechanismslblocked,lthelagentlcanlbelbactericidall(i.e.,lthe
aminoglycosides).lHowever,lMostlantibioticslthatlworklbylthislmechanismlarelbacteriostatic.
4.lBlockinglbacteriallDNAlreplication,lprobablylbylinterferinglwithlalspecificlenzymel(DNAlgy
rase).lThislmechanismlislusuallylbactericidallbutlcanlbelbacteriostaticldependinglonltheldose.
5.lPreventionloflnucleiclacidlsynthesislbylblockinglmRNAlandlsecondarilylpreventinglselectedl
proteinlsynthesis.lThislmechanismlislusuallylbactericidal.
6.lBlockinglfoliclacidlsynthesis:lThislislanlessentiallmetabolitelinlbacteriallmetabolismlthatlthel
bacteriumlmustlsynthesize.lBylblockinglthelsynthesisloflfoliclacid,lseverallmetaboliclprocessesl
arelinhibited.lThislprocesslislusuallylbacteriostatic.



Q:lBACTERIALlANTIBIOTIClRESISTANCE
-lResistanceltolantibioticslcanlbe:
(A)lIntrinsicl-l

Answer:
Resistancelthatlhaslalwayslexistedlinlthelstructureloflthelbacteria;litlislalwayslinherentlinlthelge
neticsloflthatlparticularlspecies.l(Forlexample,lgram-negativelbacterialare
nowlandlhavelalwayslbeenlresistantltolspecificlantibioticlagents.)



Q:lBACTERIALlANTIBIOTIClRESISTANCE
-lResistanceltolantibioticslcanlbe:
(B)lAcquiredl

Answer:
Resistancelthatloriginateslinlanlindividuallbacteriumlaslalresultloflalchromosomallmutationlorlt
heltransferloflchromosomallfragmentsloflDNAl(plasmidslorltransposons)lbetweenlbacterialthatli
slinducedlinlthemlbecauseloflcurrentlorlpriorlexposurelto
anlantibioticlagent.lAcquiredlresistancelusuallylresultslfromlselectivelantibioticlexposure,lwhich
lcanlresultlfromleitherlappropriatelorlinappropriatelusageloflthelantibioticlagent.



Q:lMECHANISMSlOFlANTIBIOTIClRESISTANCEl
Answer:
1.lImpermeabilityloflthelbacteriallcelllwallltolthelantibiotic

, 2.lActiveleffluxloflthelantibioticlfromlthelbacteriumlbeforelthelpharmacodynamicsloflthelantibi
oticlcanlbecomeleffective
3.lPlasmid-mediatedlalterationlorlinactivationloflthelantibioticlbylbacterially-
synthesizedlenzymes
4.lAlterationloflthelbacteria'sltargetlsite;lanlactionloflthelbacteriumlitself.
5.lBypassloflanlantibiotic-obstructedlmetaboliclpathway
6.lStructurallchangeloflanlantibiotic-bindinglsite
7.lStructurallchangeloflalbacteriallcelllcomponentlthatlislusuallylalteredlbylthelantibiotic



Q:lClassificationloflBacteriallOrganisms
GRAMlPOSITIVElAEROBESl(theselbacterialrequireloxygenltolsurvive)
-Coccil

Answer:
olstaphylococcus
olstreptococcus
olpneumococcus



Q:lClassificationloflBacteriallOrganisms
GRAMlPOSITIVElAEROBESl(theselbacterialrequireloxygenltolsurvive)
-Bacillil

Answer:
olcorynebacterium
ollisterial-linlquiz
olbacilluslanthracisl(Anthrax)



Q:lGRAMlPOSITIVElANAEROBESl(theselbacterialcanllivelinldeepltissueslwithllowllevelslo
floxygen)l

Answer:
-lclostridium
-lpeptococcus
-lpeptostreptococcus



Q:lGRAMlNEGATIVElAEROBES
-lCoccil

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller nurse_steph. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $10.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

56326 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$10.99
  • (0)
Add to cart
Added