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Exam (elaborations)

Advanced pathophysiology exam

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Advanced pathophysiology exam

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  • December 5, 2024
  • 85
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
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1. What are clinical manifestations of hypothyroidism?
B B B B B




a. Intolerance to heat, tachycardia, and weight loss
B B B B B B




b. Oligomenorrhea, fatigue, and warm skin B B B B




c. Restlessness, increased appetite, and metrorrhagia
B B B B




d. Constipation, decreased heart rate, and lethargy -
B B B B B B




answer>>The lower levels of thyroid hormone result in de
B B B B B B B B B



creased energy metabolism, resulting in constipation, bra
B B B B B B




dycardia, and lethargy, thus eliminating the remainingopti
B B B B B B B



ons.


1. Thyroid-
stimulating hormone (TSH) is released to stimulate thyroid horm
B B B B B B B B




one (TH) and is inhibited when plasma levels of THare adequate.
B B B B B B B B B B B B




This is an example of:
B B B B




a. Positive feedback B

,b. Neural regulation B B




c. Negative feedback
B B




d. Physiologic regulation -
B B B




answer>>Negative feedback. Feedback systems provide precise
B B B B B B B




monitoring and control of the cellular environment. Negative fee
B B B B B B B B




dback occurs because the changing chemical, neural, or endocrin
B B B B B B B B




e response to a stimulus negates the initiating change that trigger
B B B B B B B B B B



ed the releaseof the hormone. Thyrotropin-
B B B B B B




releasing hormone (TRH) from thehypothalamus stimulates TSH
B B B B B B B B



secretion from the anterior pituitary. Secretion of TSH stimulates
B B B B B B B B B




the synthesis and secretion of THs. Increasing levels of T4 and trii
B B B B B B B B B B B




odothyronine (T3) then generate negative feedback on the pituit
B B B B B B B B



ary and hypothalamus to inhibit TRH and TSH synthesis.
B B B B B B B B




1. Lipid-
B




soluble hormone receptors are located: a. Inside t
B B B B B B B




he plasma membrane in the cytoplasm
B B B B B




b. On the outer surface of the plasma membrane
B B B B B B B




c. Inside the mitochondria B B




d. On the inner surface of the plasma membrane -
B B B B B B B B




answer>>Inside the plasma membrane in the cytoplasm. Lipid-
B B B B B B B B




soluble hormone receptors are located inside the plasma
B B B B B B B B

,membrane and easily diffuse across the plasma membrane tob
B B B B B B B B B




ind to either cytosolic or nuclear receptors.
B B B B B B




1. The releasing hormones that are made in the hypothalamust
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ravel to the anterior pituitary via the:
B B B B B B




a. Vessels of the zona fasciculata B B B B




b. Hypophyseal stalk B




c. Infundibular stem B




d. Portal hypophyseal blood vessels B B B




Portal hypophyseal blood vessels. -
B B B B



answer>>Releasing and inhibitory hormones are synthesized in th
B B B B B B B B




e hypothalamus andare secreted into the portal blood vessels thr
B B B B B B B B B B



ough which theytravel to the anterior pituitary hormones.
B B B B B B B B




1. Which mineral is needed for thyroid- B B B B B



stimulating hormone(TSH) to stimulate the secretion of thyro
B B B B B B B B




id hormone (TH)?
B B




a. Iron b B B




. Iodide
B




c. Zinc B

, d. Copper -
B B




answer>>Iodide. TSH, which is synthesized and stored in the ant
B B B B B B B B B B




erior pituitary, stimulates secretion of TH by activating intracellul
B B B B B B B B




ar processes, including the uptake of iodinenecessary for the synt
B B B B B B B B B B




hesis of TH. B B




1. What effect does hyperphosphatemia have on other
B B B B B B




electrolytes?
a. Increases serum calcium B B




b. Decreases serum magnesium B B B




c. Decreases serum calcium
B B B




d. Increases serum magnesium
B B B




Decreases serum calcium. - B B B



answer>>Hyperphosphatemia leadsto hypocalcemia. Remembe
B B B B B




r that phos and calcium are inversely related.
B B B B B B B




1. Insulin transports which electrolyte in the cell?
B B B B B B




a. Potassium
b. Sodium
c. Calcium

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