Suppositories & Inserts
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- very important
- must use language the patient can un-
derstand
- average reading level of US 7th grade
- many patients have swallowed suppos-
itories and foams (because they look like
patient counseling for suppositories oral capsules)
- should be sensitive to patient feelings
- often uncomfortable and embarrassed
- specialized formulation
yes
- constipation (local)
- motion sickness (when patient cannot
take oral because they would throw up)
What conditions are suited with suppos- - seizure
itory formulations?
no
- cystic fibrosis (best formulation would
be inhalation)
- diarrhea (risk of expelling formulation)
- often small, round or cone-shaped ob-
ject (similar to capsules)
- suppositories: rectum
- inserts: vagina, and to a lesser extent,
in the ear, nose, or urethra (inserted in
any other part of the body)
- melts or dissolves once inside and re-
suppository & insert leases the drug
,Suppositories & Inserts
Study online at https://quizlet.com/_dzuluw
- a solid dosage form in which one ore
more APIs are dispersed in a suitable
base and molded or otherwise formed
into a suitable shape for insertion into
the rectum to provide local or systemic
effect.
- suppository - latin supponere, meaning
suppository "to place (ponere) under (sup)"
- usually 32 mm (1.5 inch) long, cylindri-
cal, one or both ends tapered
- end has largest diameter
- looks like a tampon
- a solid dosage form that is inserted into
a naturally occurring (nonsurgical) body
cavity other than the mouth or rectum,
insert
including the vagina and urethra
- female use only
- very common
vaginal inserts - globular, oviform, or cone shaped
- ~5 gram, but can vary greatly depend-
ing on the product
- much thinner
- more fore males
- slender, pencil-shaped
urethral inserts - male inserts: 3-6 mm in diameter, ~140
mm long, ~4 gram
- female inserts: half the length and
weight of male urethral insert
, Suppositories & Inserts
Study online at https://quizlet.com/_dzuluw
- fungal infections (bacteria)
- vaginal dryness
- birth control
vaginal inserts - uses
- clindamycin - antibiotic
- miconazole - antifungal
example of vaginal inserts and tablets - nonoxynol - birth control
- rare
- only one kind: MUSE
- men with erection problems can use to
take the drug alprostadil
- the insert is about the size of a grain of
rice
urethral inserts - example
- adult: ~2 gram (larger)
- infants and children: ~ half the weight
and size of adult suppositories; pen-
cil-like shape
suppository - shape - bullet or torpedo shaped with conical or
spherical end (round shaped head)
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