Summary
Summary RNSG 1341 Addison and Cushings disease Lecture Notes
- Course
- RNSG 1341
- Institution
- San Jacinto College
This is a comprehensive and detailed note on Addison and Cushings disease.
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ADDISON’S & CUSHING’S DISEASE• Addison’s Disease or Addisonian Crisis: Lack of adrenal cortex hormones or withdrawal
corticosteroid medication
• Cushing’s Syndrome or Disease-Excess adrenal cortex hormones or too much
corticosteroid medication
• Adrenal Cortex hormones:
• Stimulated by ACTH release from anterior pituitary
Glucocorticoids
• Regulate metabolism (fat, protein, carbohydrate) ↑ blood glucose
• Suppress inflammation
• Critical in physiologic stress response
• Control sleep/wake pattern
• Can decrease bone formation
Mineralocorticoids-Aldosterone
• Regulate sodium and potassium balance
• Regulate fluids
Androgens
• Involved in growth and development, sexual activity
ADDISON’S DISEASE
, Primary (it’s the adrenal cortex’s fault)
• Addison’s disease
• Lack of glucocorticoids, mineralocorticoids, and androgens
Secondary (it’s the pituitary’s fault)
• Lack of pituitary ACTH
• Lack of glucocorticoids and androgens
One other: withdrawal of corticosteroid medication
Autoimmune response against adrenal cortex-70-90%
• May have other autoimmune diseases: Type I diabetes, autoimmune thyroid
diseases, pernicious anemia, celiac disease)
TB (uncommon in US), fungal infections, AIDS, metastatic cancer
Iatrogenic (illness caused by treatment):
• e.g. Adrenal hemorrhage-anticoagulants, surgery-adrenalectomy, drugs-
chemotherapy.
S/S
• Hyperpigmentation
• Orthostatic hypotension
• ↓ Na and salt craving
• ↑K
• ↑ Ca
• Abdominal Pain, nausea and vomiting, diarrhea
• ↓ glucose
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