2024
USMLE Step 2 Pharma Test 1 ||
Questions & Solutions (Graded A+)
CONCEPTIAL RESEARCH
Conceptialresearch@gmail.com
, USMLE Step 2 Pharma Test 1 ||
Questions & Solutions (Graded A+)
Induction of P450 (7) - ANSWER - Quinidine, Barbiturates, St.Johns wart, Phenytoin,
Rifampin, Griseofulvin, Carbamazepine
Queen Barb Steels Phen-Phen and Refuses Creasy Carbs
Side effect of ACEIs - ANSWER - Cough, rash, proteinuria, angioedema (days/weeks
but anytime) taste changes, teratonenic
Side effect of amantadine - ANSWER - ataxia, livedo reticularis
Side effect of aminoglycosides - ANSWER - ototox, nephrotox (acute tub necrosis)
Side effect of amiodarone - ANSWER - acute:
AV block, hypotension, bradycardia
chron:
pul fibrosis, bluish skin, arrythmias, hypothyroidism, corneal deposition, hepatotox
Side effect of amphotericine - ANSWER - fever/rigor, nephrotox, BM supp, anemia
Side effect of antipsychotics - ANSWER - sedation, acute dystonia, akathsia,
parkinsonism, tarditive dyskinesia, NMS
Side effect of Azoles - ANSWER - Inhib of P450
Side effect of AZT - ANSWER - thrombocytopenia, megaloblast anemia
Side effect of ßBlocker - ANSWER - Athma exazerb, masking hypoglycemia,
impotence, bracycardia, AV block, CHF
Side effect of Benzodiazep - ANSWER - Sedation, dependence, resp. depression
Side effect of bile acid resins - ANSWER - GI upset, malabs of vitamines and meds
Side effect of carbamazepine - ANSWER - P450 induction, agranulozytosis, aplastic
anemia, livertox
Side effect of CCBs - ANSWER - periph edema, constipation, cardiac depri
Side effect of chloramphenicole - ANSWER - gray baby s, aplastic anemia
, Side effect of cisplatin - ANSWER - nephrotox, acustic nerve damage
Side effect of clonidine - ANSWER - dry mouth, severe rebound headache and
hypertension
Side effect of clozapine - ANSWER - agranulocytosis
Side effect of corticosteroids - ANSWER - mania, hyperglycemia (acute), immusupp,
bone mineral loss, skin thinning, bruising, myopathy, cataracts (chronic)
Side effect of cyclophosphamide - ANSWER - myelosupp, hermorr cystitis
Side effect of digoxin - ANSWER - GI problems, yellow vision change, arrhythmia
(junctional tachy and SVT)
Side effect of doxorubicine - ANSWER - cardiomyophathy
Side effect of ethyl alc - ANSWER - acidosis, renal dysfkt, cns depri
Side effect of acyclovir - ANSWER - nephrotox via crystalluria (10%) - give aggressive
hydration
Inhibition of P450 (6) - ANSWER - Cimetidine, Ketokonazole, IHN, Grapefruit,
Erythromycine, Solfonamides
Metabolized via P450 - ANSWER - Benzodiazepines, Amide anesthetics, Metoprolol,
propanolol, nifedipine, phenytoin, quinidine, theophyline, warfarin, barbituartes
meds risking digoxin toxicity (4) - ANSWER - Quinidine, cimetidine, amiodarone, CCBs
Albumin binding side competition drugs (3) - ANSWER - Warfarin, ASA, phenytoin
drugs causing blood dyscrasia - ANSWER - Ibuprofene, quinidine, methyldopa,
chemotx
Hemolysis causing drugs in G6PD - ANSWER - Sulfonamides, INH, ASA, Ibuprofene,
nitrofurantoin, Primaquine, pyrimethamine, chloramphenicole
Gynecomastasia causing drugs - ANSWER - Spironolactone, Estrogenes, Digitalis,
Cimetidine, chonic alk, ketokonazole
Steven Johnson causing drugs - ANSWER - Anticonvulsants, sulfonamides, penicillins
Photosensitivity causing drugs - ANSWER - Tetracycline, Amiodarone, Sulfonamides
