Biochemistry USMLE Step 1 Exam || With Questions & Solutions (Graded A+)
Biochemistry USMLE Step 1 Exam || With Questions & Solutions (Graded A+)
Allopurinol is used for the treatment of chronic gout because it __________. - ANSWER - Decreases uric acid levels by blocking xanthine oxidase with ...
, Biochemistry USMLE Step 1 Exam ||
With Questions & Solutions (Graded A+)
Allopurinol is used for the treatment of chronic gout because it __________. - ANSWER
- Decreases uric acid levels by blocking xanthine oxidase with converts hypoxanthing to
xanthine and then to uric acid
Lesch-Nyhan is a X-lined recessive disorder due to __________. - ANSWER - absence
of HGPRT--thus patients are unable to salvage purines leading to excessive de novov
synthesis which then leads to excess uric acid production.
The presentation of retardation, cerebral palsy, slef-mutiliation, gout and "crystals in
diaper" and self-muilation is most consistent with ________. - ANSWER - Lesch-
Nyahan Syndrome
What is the treatment for Lesch-Nyhan syndrome? - ANSWER - Allopurinol (inhibits
xanthine oxidase in the purine salvage pathway, thus reducing excess production of uric
acid)
What disorder is associated with hyperuricenmis either due to overproduction or
underexcretion of uric acis and is characterized by sodium urate crystal deposits in the
joints and soft tissues? - ANSWER - Gout
What are some causes of uric acid overproduction in acquired gout? - ANSWER -
Leukemia, alcoholism, myelopproliferative syndrome, multiple myeloma, hemolysis,
neoplasia, psoriasis
What drugs are associated with urate underexcretion in acquired gout? - ANSWER -
Aspirin, diuretics, alcohol
What is podagra? - ANSWER - Gout of the great toe
Monoarticular arthirits of distal joints often with a history of hyperuricemia percipiatated
by a sudden change in urate levels (due to large meals, alcohol) is characteristic of
______ and can eventually lead to the formation of _______. - ANSWER - gout; nodular
tophi (urate crystals surrounded by fibrous connective tissue) located around the joints
and Achilles tendon.
How is gout diagnosed? - ANSWER - Detection of negatively bifringent crystals from
articular tap, arthritis and hyperuricemia
What is the treatment for Gout? - ANSWER - For chronic-allopurinol to lower uric acid
levels but NOT for acute treatment. For aute treatment decrease pain and inflammation
with colchicines and NSAIDS and avoidance of large meals and ETOH
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