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Unit 4 test UNE medical biochemistry Exam Questions and Answers 100% Pass

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Unit 4 test UNE medical biochemistry Exam Questions and Answers 100% Pass A deficiency in which of the following enzymes will NOT result in an increase in orotic acid? a. N-acetylglutamate synthetase b. Ornithine transcarbamoylase c. Argininosuccinate synthetase d. Argininosuccinate lyase - N...

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  • January 8, 2025
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  • 2024/2025
  • Exam (elaborations)
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  • UNE Biochemistry
  • UNE Biochemistry
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EmilyCharlene
Unit 4 test UNE medical biochemistry
Exam Questions and Answers 100% Pass

A deficiency in which of the following enzymes will NOT result in an increase in orotic acid?


a. N-acetylglutamate synthetase


b. Ornithine transcarbamoylase


c. Argininosuccinate synthetase


d. Argininosuccinate lyase - ✔✔N-acetylglutamate synthetase (NAG synthetase




Feedback: deficiencies in NAG synthetase or carbamoyl phosphate synthetase I will NOT result in an

increase in orotic acid.


Which of the following enzymes is correctly paired with its activator?




a. N-acetylglutamate synthtase; arginine


b. Carbamoyl phosphate synthetase I; ATP


c. Glutaminase; citrate


d. Arginase; NADH - ✔✔N-acetylglutamate synthtase; arginine




EMILY CHARLENE © 2025, ALL RIGHTS RESERVED 1

, Feedback: arginine (an intermediate of the urea cycle), stimulates the synthesis of NAG by allosterically

activating the enzyme N-acetylglutamate synthase


Which of the following enzymes is regulated by N-acetylglutamate (NAGs)?




a. Carbamoyl phosphate synthetase II


b. Ornithine transcarbamoylase


c. Carbamoyl phosphate synthetase I


d. Arginosuccinate lyase - ✔✔Carbamoyl phosphate synthetase I (CPS I)




Feedback: CPS I is the regulatory enzyme of the urea cycle and is stimulated by NAG


Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-acetylglutamate

(NAGs). Which of the following will be a consequence of this deficiency in the patient?


a. increased fatty acids in the blood


b. increased amino acids in the blood


c. decreased excretion of uric acid


d. increased glucose in the blood - ✔✔Increased amino acids in the blood




NAG is an essential activator of CPS I which catalyzes the first step in the urea cycle. Loss of this activator

will decrease urea cycle activity, which will increase the amount of amino acids in the blood.


The urea cycle takes place in which of the following subcellular locations?




EMILY CHARLENE © 2025, ALL RIGHTS RESERVED 2

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