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UNE Biochemistry Unit 2 Test Questions and Answers 100% Pass
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UNE Biochemistry Unit 2 Test Questions and Answers 100% Pass 3, 2, 4, 1 - Order the following statements to illustrate the correct cascade of events that occurs after ligand binding of G-protein coupled receptor (heptahelical receptor). 1. Degradation of cAMP by phosphodiesterase 2. Dissociati...

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  • January 8, 2025
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  • 2024/2025
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UNE Biochemistry Unit 2 Test
Questions and Answers 100% Pass

3, 2, 4, 1 - ✔✔Order the following statements to illustrate the correct cascade of events that occurs after

ligand binding of G-protein coupled receptor (heptahelical receptor).




1. Degradation of cAMP by phosphodiesterase




2. Dissociation of Gβ and Gγ subunits




3. G protein exchanges GDP for GTP in the G-αs subunit




4. Activation of adenylyl cyclase (effector E) to generate cAMP


Nuclear localization signal - ✔✔A suspected mutation in the cortisol receptor is discovered. Cortisol can

still bind its receptor but the dimerized complex remains in the cytosol. Based on this description which

region on the receptor is likely impacted?


Free fatty acids - ✔✔What is the primary oxidized fuel for skeletal muscle in the fasted state?




EMILY CHARLENE © 2025, ALL RIGHTS RESERVED 1

, Glucagon - ✔✔Caffeine is a natural inhibitor of phosphodiesterase. If you were to consume a large

amount of coffee you would likely see a prolonged response to which of the following stimulants or

hormones?


Protein Kinase B - ✔✔In the event that PI-3 kinase is not activated downstream of insulin, which of the

following proteins would not be able to dock to the membrane?


Gluconeogenesis - ✔✔A patient is found to have a rare disease in which the secretory function of the α-

cells of the pancreas is impaired. As a consequence, glucagon cannot be secreted. Direct stimulation of

which of the following pathways in liver will be impaired?


Phosphodiesterase - ✔✔What enzymes is responsible for the degradation of cAMP?


VLDL particles - ✔✔Insulin stimulates fatty acid synthesis in the liver. These fatty acids are transported

to the adipose tissue as which of the following?


Phosphofructokinase-1 (PFK1) - ✔✔After a meal, fructose 2,6-bisphosphate levels are elevated. This

compound will allosterically activate which of the following glycolytic enzymes?


Aconitase - ✔✔A farmer finds a cow dead in his field and notices an unusual plant nearby. Autopsy

results show an elevated level of citrate present in the cow's mitochondria. This data collectively suggest

inhibition of which of the following enzymes?


Pyruvate - ✔✔A deficiency in thiamine can reduce the activity of the pyruvate dehydrogenase complex.

Under these conditions, you would expect to have a higher than normal blood concentration of which of

the following metabolites?


Succinate thiokinase - ✔✔A 10-year-old girl is swimming in a local competition. The intense exercise will

increase intracellular calcium levels which in turn will increase flux through the TCA cycle by stimulating

the activity of all of the following enzymes EXCEPT?




EMILY CHARLENE © 2025, ALL RIGHTS RESERVED 2

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