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MCB 450 Lon-Capa And Clickers Exam 4 Questions And Answers With Verified Solutions Already Passed Rated A+ $15.99
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MCB 450 Lon-Capa And Clickers Exam 4 Questions And Answers With Verified Solutions Already Passed Rated A+

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MCB 450 Lon-Capa And Clickers Exam 4 Questions And Answers With Verified Solutions Already Passed Rated A+

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  • January 9, 2025
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MCB 450 Lon-Capa And Clickers Exam 4
Questions And Answers With Verified
Solutions Already Passed Rated A+
High levels of ATP and citrate:
Answer: D. All of the above
Explanation: High ATP and citrate indicate a high-energy, well-fed state. These
conditions signal that the body does not need to produce more energy, inhibiting
glycolysis and promoting gluconeogenesis.

LOW pyruvate dehydrogenase rate is associated with:
Answer: A. High Acetyl CoA
Explanation: High levels of Acetyl-CoA inhibit pyruvate dehydrogenase activity,
which reduces the conversion of pyruvate to Acetyl-CoA.

Hallmarks of acute alcoholism without food intake (acidosis and
hypoglycemia) are due to:
Answer: E. Cellular metabolism of alcohol generates a high ratio of NADH/NAD,
which shuts down liver gluconeogenesis. The body increases lipolysis and utilizes
fat as an energy source that produces large amounts of ketone bodies and lactate.

Hormonal activation of cyclic AMP levels will:
Answer: E. Increase the activation of gluconeogenesis.
Explanation: Cyclic AMP (cAMP) activates protein kinase A (PKA), which
activates enzymes involved in gluconeogenesis.

Which vitamins are precursors to coenzymes necessary for acetyl CoA
formation from pyruvate?
Answer: C. Thiamine, riboflavin, niacin, lipoic acid, and pantothenic acid

In addition to pyruvate dehydrogenase, what other enzyme(s) in the citric acid
cycle use thiamine pyrophosphate?
Answer: A. α-ketoglutarate dehydrogenase

True or False: TPP takes the acetyl group from lipoamide.
Answer: False

,True or False: The aconitase reaction isomerizes Citrate to Isocitrate through
an enediolate intermediate.
Answer: False

True or False: The aconitase reaction isomerizes Citrate to Isocitrate through
an alkene intermediate.
Answer: True

True or False: A biotin-deficient diet may lead to an increase of cytosolic
acetyl CoA.
Answer: True

True or False: The brain uses fructose instead of glucose for ATP production
during long-term fasting.
Answer: False

True or False: The thiol group of CoA attacks the amide bond of
acetyllipoamide to create the thioester bond of acetyl-CoA.
Answer: False

True or False: CoA directly attacks pyruvate leading to a loss of CO2.
Answer: False

True or False: Fructose 2,6-bisphosphate activates glycolysis and inhibits
gluconeogenesis via conversion of fructose 1,6-bisphosphate.
Answer: True

True or False: The conversion of glucose 6-phosphate to glucose takes place in
the endoplasmic reticulum.
Answer: True

True or False: In the citric acid cycle, GTP is produced by a substrate-level
phosphorylation.
Answer: True

True or False: Lipoamide is covalently linked to E2 of pyruvate
dehydrogenase through a thioester bond to the side chain of a Cys residue.
Answer: False

, True or False: Oxaloacetate is carboxylated and then phosphorylated to
produce phosphoenolpyruvate.
Answer: False

True or False: The first step of gluconeogenesis takes place in the cytosolic
compartment.
Answer: False

True or False: Coenzyme A is an activated carrier of CO2.
Answer: False

True or False: Gluconeogenesis is not the exact reversal of all steps in
glycolysis.
Answer: True

True or False: Carbons from glucose enter the citric acid cycle in the form of
acetyl CoA.
Answer: True

Why does acetyl CoA influence the pyruvate dehydrogenase complex (PDH)?
Answer: C. When fatty acid breakdown is high, PDH is inhibited by acetyl CoA
due to pyruvate kinase activity.

What is the link between the citric acid cycle and O2?
Answer: D. A primary product of the citric acid cycle is NADH, the principle
electron donor to the O2, the last electron acceptor in the electron-transport system.

Chemical changes involved in the conversion of citrate into isocitrate:
Answer: B. Dehydration followed by hydration

Condition that activates pyruvate dehydrogenase kinase:
Answer: A. Elevated concentrations of NADH and ATP

What is the direct movement of substrates from one enzyme to the next
called?
Answer: B. Substrate channeling

What would a mutation in the active site of succinyl CoA synthetase (His to
Lys) result in?
Answer: A. Loss of a succinyl phosphate intermediate

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