Does not involve antigen/antibody complexes like Types 1, 2 and 3
Is T-cell mediated
6. Differentiating Between the Rash of a Type 1 vs. Type 4 Reaction:: Type 1:
Immediate hypersensitivity reactions, termed atopic dermatitis, are usually charac-
terized by widely distributed lesions
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only at the
site of contact with the allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison ivy
7. Treatment of Type 4 Rash: A non-severe case of contact dermatitis would be
treated with topical corticosteroid.
Why not epinephrine or antihistamines?
-Epinephrine is for emergent Type 1 anaphylactic reactions. Antihistamines act onthe
H1 receptors. Type 4 does not involve mast cells and H1 receptors.
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