Rubin's Pathology: Clinicopathologic Foundations of Medicine Seventh Edition test bank with answers
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Course
Pathology
Institution
Pathology
Chapter 1: Cell Adaptation, Injury and Death
1. Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a result of:
A) release of stored calcium from the mitochondria.
B) improved intracellular volume regulation.
C) decreased influx across the cell membrane.
...
A) releasefxoffxstoredfxcalciumfxfromfxthefxmitochondria.
B) improvedfxintracellularfxvolumefxregulation.
C) decreasedfxinfluxfxacrossfxthefxcellfxmembrane.
D) attractionfxoffxcalciumfxtofxfattyfxinfiltrates.
Thefxpatientfxisfxfoundfxtofxhavefxliverfxdisease,fxresultingfxinfxthefxremovalfxoffxafxlobefxoffxh
2. isfxliver.fxAdaptationfxtofxthefxreducedfxsizefxoffxthefxliverfxleadsfxtofx
offxthefxremainingfxliverfxcel
ls.
A) metaplasia
B) organfxatrophy
C) compensatoryfxhyperplasia
fxfx D physiologicfxhypertrophy
)
Afxpersonfxeatingfxpeanutsfxstartsfxchokingfxandfxcollapses.fxHisfxairwayfxobstructionfxisfx
partiallyfxcleared,fxbutfxhefxremainsfxhypoxicfxuntilfxhefxreachesfxthefxhospital.fxThefxprolo
3. ngedfxcellfxhypoxiafxcausedfxafxcerebralfxinfarctionfxandfxresultingfx infxthefxbrain.
A) caspasefxactivation
B) coagulationfxnecrosis
C) rapidfxphagocytosis
D) proteinfxp53fxdeficiency
Bacteriafxandfxvirusesfxcausefxcellfxdamagefxbyfx
4. ,fxwhichfxisfxuniquefxfromfxthefxintracell
ularfxdamagefxcausedfxbyfxotherfxinjuriousfxagents.
A) disruptingfxthefxsodium/potassiumfxATPasefxpump
B) interruptingfxoxidativefxmetabolismfxprocesses
fxfx C replicatingfxandfxproducingfxcontinuedfxinjury
)
D) decreasingfxproteinfxsynthesisfxandfxfunction
Thefxpatientfxhasfxafxprolongedfxinterruptionfxinfxarterialfxbloodfxflowfxtofxhisfxleftfxkidney,fxcausi
5. ngfxhypoxicfxcellfxinjuryfxandfxthefxreleasefxoffxfreefxradicals.fxFreefxradicalsfxdamagefxcellsfxby:
A) destroyingfxphospholipidsfxinfxthefxcellfxmembrane.
B) alteringfxthefximmunefxresponsefxoffxthefxcell.
C) disruptingfxcalciumfxstoragefxinfxthefxcell.
, D) inactivationfxoffxenzymesfxandfxmitochondria.
6. Injuredfxcellsfxhavefximpairedfxflowfxoffxsubstancesfxthroughfxthefxcellfxmembranefxasfxafxresultfxo
A) increasedfxfatfxload.
B) alteredfxpermeability.
C) alteredfxglucosefxutilization.
D) increasedfxsurfacefxreceptors.
7. Reversiblefxadaptivefxintracellularfxresponsesfxarefxinitiatedfxby:
A) stimulusfxoverload.
B) geneticfxmutations.
C) chemicalfxmessengers.
D) mitochondrialfxDNA.
8. Injuredfxcellsfxbecomefxveryfxswollenfxasfxafxresultfxof:
A) increasedfxcellfxproteinfxsynthesis.
B) alteredfxcellfxvolumefxregulation.
C) passivefxentryfxoffxpotassiumfxintofxthefxcell.
D) blebfxformationfxinfxthefxplasmafxmembrane.
Afxdiabeticfxpatientfxhasfximpairedfxsensation,fxcirculation,fxandfxoxygenationfxoffxhisfxfeet.fxHef
xstepsfxonfxafxpiecefxoffxglass,fxthefxwoundfxdoesfxnotfxheal,fxandfxthefxareafxtissuefxbecomesfxne
9. crotic.fxThefxnecroticfxcellfxdeathfxisfxcharacterizedfxby:
A) rapidfxapoptosis.
B) cellularfxrupture.
C) shrinkagefxandfxcollapse.
D) chronicfxinflammation.
Afx99-year-
10. oldfxwomanfxhasfxexperiencedfxthefxdeclinefxoffxcellfxfunctionfxassociatedfxwithfxage.fxAfxgroup
fxoffxtheoriesfxoffxcellularfxagingfxfocusfxonfxprogrammed:
A) changesfxwithfxgeneticfxinfluences.
B) eliminationfxoffxcellfxreceptorfxsites.
C) insufficientfxtelomerasefxenzyme.
fxfx D DNAfxmutationfxorfxfaultyfxrepair.
)
Anfx89-year-
oldfxfemalefxpatientfxhasfxexperiencedfxsignificantfxdecreasesfxinfxherfxmobilityfxandfxstaminaf
xduringfxafx3-
11. weekfxhospitalfxstayfxforfxthefxtreatmentfxoffxafxfemoralfxheadfxfracture.fxWhichfxof
thefxfollowingfxphenomenafxmostfxlikelyfxaccountsfxforfxthefxpatientsfxdecreasefxinfxmusclefxfu
A) Impairedfxmusclefxcellfxmetabolismfxresultingfxfromfxmetaplasia
B) Dysplasiafxasfxafxconsequencefxoffxinflammationfxduringfxbonefxremodeling
C) Disusefxatrophyfxoffxmusclefxcellsfxduringfxafxprolongedfxperiodfxoffximmobility
D) Ischemicfxatrophyfxresultingfxfromfxvascularfxchangesfxwhilefxonfxbedrest
Afx20-year-
oldfxcollegefxstudentfxhasfxpresentedfxtofxherfxcampusfxmedicalfxclinicfxforfxafxscheduledfxPapani
12. colaoufx(Pap)fxsmear.fxThefxclinicianfxwhofxwillfxinterpretfxthefxsmearfxwillfxexaminefxcellfxsa
mplesfxforfxevidencefxof:
A) changesfxinfxcellfxshape,fxsize,fxandfxorganization.
B) thefxpresencefxoffxunexpectedfxcellfxtypes.
fxfx C) ischemicfxchangesfxinfxcellfxsamples.
D) abnormallyfxhighfxnumbersfxoffxcellsfxinfxafxspecifiedfxfield.
Whichfxoffxthefxfollowingfxpathophysiologicfxprocessesfxisfxmostfxlikelyfxtofxresultfxinfxmetastati
fxfx 13 cfxcalcification?
.
A) Benignfxprostaticfxhyperplasia
B) Liverfxcirrhosis
C) Impairedfxglycogenfxmetabolism
D) Hyperparathyroidism
Despitefxthefxlowfxlevelsfxoffxradiationfxusedfxinfxcontemporaryfxradiologicfximaging,fxafxradiol
ogyfxtechnicianfxisfxawarefxoffxthefxneedfxtofxminimizefxherfxexposurefxtofxionizingfxradiation.fx
14. Whatfxisfxthefxprimaryfxrationalefxforfxthefxtechniciansfxprecautions?
A) Radiationfxstimulatesfxpathologicfxcellfxhypertrophyfxandfxhyperplasia.
B) Radiationfxresultsfxinfxthefxaccumulationfxoffxendogenousfxwastefxproductsfxinfxthefxcytopla
m.
C) RadiationfxinterferesfxwithfxDNAfxsynthesisfxandfxmitosis.
D) Radiationfxdecreasesfxthefxactionfxpotentialfxoffxrapidlyfxdividingfxcells.
Thefxparentsfxoffxafx4-year-
oldfxgirlfxhavefxsoughtfxcarefxbecausefxtheirfxdaughterfxhasfxadmittedfxtofxchewingfxandfxswallo
15. wingfximportedfxtoyfxfigurinesfxthatfxhavefxbeenfxdeterminedfxtofxbefxmadefxoffxlead.fxWhichfxoff
xthefxfollowingfxbloodfxtestsfxshouldfxthefxcarefxteamfxprioritize?
fxfx A) Whitefxbloodfxcellfxlevelsfxwithfxdifferential
B) Redfxbloodfxcellfxlevelsfxandfxmorphology
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