NR 546/ NR546 FINAL EXAM: (NEW 2025/ 2026 UPDATE) ADVANCED PHARMACOLOGY: PSYCHOPHARMACOLOGY FOR THE PMHNP REVIEW| QUESTIONS & ANSWERS| GRADE A| 100% CORRECT (VERIFIED SOLUTIONS)- CHAMBERLAINNR 546/ NR546 FINAL EXAM: (NEW 2025/ 2026 UPDATE) ADVANCED PHARMACOLOGY: PSYCHOPHARMACOLOGY FOR THE PMHNP R...
10. MAOIs - ANS ✓Last choice medication class for depression due to the many
potential, serious side effects. MAOIs have specific dietary restrictions that when
ignored, may be very uncomfortable or very serious for clients.
11. MAOIs - ANS ✓Drugs:
· phenelzine (Nardil)
· selegiline (Emsam) - MAOI-B
· tranylcypromine (Parnate)
· isocarboxazid (Marplan)
12. MAOI's Key Points - ANS ✓· Clients taking MAOIs are at high risk for
hypertensive crisis if tyramine is ingested.
· Do not prescribe any serotonergic agents within 2 weeks of MAOI discontinuation due to an
increased risk of serotonin syndrome.
NR 546
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NR
Wait at least 5 half-lives after discontinuing a serotonergic medication before initiating an
MAIO.
13. Foods to Avoid When Taking MAO-A Medications - ANS ✓· Red wine (Avoid)
· Sauerkraut (Avoid)
· Cheese (Avoid)
· Soy (Avoid)
· Smoked meats (Avoid)
14. Foods to Avoid When Taking MAO-A Medications - ANS ✓Rationale: Limiting
the consumption of tyramine is necessary for orally available MAOIs due to inhibition
of MAO-A in the gut. Dietary restrictions are not required for the transdermal
formulation of selegiline.
Tyramine is present in many aged or preserved foods including aged cheeses, tap and non-
pasteurized beers, aged or smoked meat or fish, sauerkraut, kimchee, soy products, and tofu.
Foods to be avoided when taking MAO-A medications include wine, meats, sauerkraut,
cheese, and soy.
15. Newer Treatments for Resistant Depression - ANS ✓· The goal of antidepressant
treatment is the remission of symptoms; however, the current treatment response of
clients with mood disorders varies widely and is often unsatisfactory.
· For example, in clients with MDD, the treatment efficacy of selective serotonin reuptake
inhibitors (SSRIs), the most used first-line pharmacological agent is between 48 and 64%
with reported remission rates as low as 23.5%.
NR 546
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